Safety of ivermectin: toxicity and adverse reactions in several mammal species
Journal Title: Revista MVZ Cordoba - Year 2010, Vol 15, Issue 2
Abstract
The antiparasitic drug Ivermectin is frequently used in veterinary medicine, due to its broad spectrum of activity (both against endo- and ectoparasites, high efficacy and wide margin of safety. However, its administration can give rise to toxic effects. Most of them come from the overdosage of the compound, although, at therapeutic doses, it also has been described an increased susceptibility to Ivermectin toxicosis in some breeds and subpopulations of animals, as well as severe anaphylactic reactions due to the sudden massive release of parasite toxins.
Authors and Affiliations
Aránzazu González-Canga, Ph. D *| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España.Correspondencia: agonc@unileon.es, Nélida Fernández-Martínez, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España., Ana Sahagún-Prieto, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España., Juan García-Vieitez, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España., María José Díez Liébana, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España., Pedro Pablo Tamame-Martín, M. Sc| Matadero GYPISA-Talavera. Talavera de la Reina, Toledo., Matilde Sierra-Vega, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España.
Keywords
Related Articles
- EP ID EP3166
- DOI -
- Views 346
- Downloads 27
Reef fish community in presence of the lionfish (Pterois volitans) in Santa Marta, Colombian Caribbean
Objective. Fish species community structure and benthic organisms coverage were studied in five localities in Santa Marta where the lionfish is present. Materials and methods. Abundance of fish species, including lion fi...
Population genetic structure of bovine lactoferrine gen in holstein breed of Antioquia Department
Estimate some population structure parameters in a Holstein population of the Department of Antioquia.Research involved 427 Holstein cows of five municipalities in the department of Antioquia. The cattle was genotyped us...
Serological evidence of Hepatitis E Virus infection in Antioquia, Colombia slaughtered pigs
Objective. To detect the presence of specific antibodies against Hepatitis E virus (HEV) in pigs slaughtered in Antioquia, the department where the greatest amount of pork is produced and consumed in Colombia. Materials...
Influence of gastrointestinal parasitism on biochemical variables in blood of laying hens
Objective. This study describes the influence of endoparasites and diet on biochemical variables in sera of brown laying hens. Materials and methods. Biochemical parameters (seric levels of cholesterol, triglycerides, to...
Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattle
Objective. Due to the importance of controlling ectoparasites, associated with the necessity of technical knowledge on the safety of topical treatment with organophosphates, pyrethroids and piperonyl butoxide to the anim...