Safety of ivermectin: toxicity and adverse reactions in several mammal species
Journal Title: Revista MVZ Cordoba - Year 2010, Vol 15, Issue 2
Abstract
The antiparasitic drug Ivermectin is frequently used in veterinary medicine, due to its broad spectrum of activity (both against endo- and ectoparasites, high efficacy and wide margin of safety. However, its administration can give rise to toxic effects. Most of them come from the overdosage of the compound, although, at therapeutic doses, it also has been described an increased susceptibility to Ivermectin toxicosis in some breeds and subpopulations of animals, as well as severe anaphylactic reactions due to the sudden massive release of parasite toxins.
Authors and Affiliations
Aránzazu González-Canga, Ph. D *| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España.Correspondencia: agonc@unileon.es, Nélida Fernández-Martínez, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España., Ana Sahagún-Prieto, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España., Juan García-Vieitez, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España., María José Díez Liébana, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España., Pedro Pablo Tamame-Martín, M. Sc| Matadero GYPISA-Talavera. Talavera de la Reina, Toledo., Matilde Sierra-Vega, Ph. D| Universidad de León. Departamento de Ciencias Biomédicas. Área de Farmacología. León. España.
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