Saxagliptin versus Glimepiride Combination with Metformin in Type 2 Diabeted Mellitus
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 3
Abstract
Abstract: Various groups of oral hypoglycemic agents (OHAs) are recently available, but there is a need for agents with different mechanisms of action that achieve better efficacy and can be used either as monotherapy or in combination with treatment regimens. Dipeptidyl peptidase-4 inhibitors improve glycemic control in patients with type 2 diabetes mellitus (T2DM) when used as monotherapy or in combination with other OHAs. The main aim of the present study is to compare the effects of Saxagliptin versus Glimepiride on efficacy of treatment in patients with T2DM in combination with metformin. A retrospective observational study will be performed on patients each in (Saxagliptin+Metformin) and (Glimepiride+Metformin) group, who are receiving treatment for at least 12 weeks. Glycated hemoglobin (HBA1c) will be the chief parameter of efficacy. At 12 weeks both groups (Saxagliptin and Glimepiride) produced significant (P < 0.05) reduction in HbA1C, with 51.4% of patients in saxagliptin group and 25.7% of patients in glimepiride group achieving target HbA1C. Reduction was also significant (P < 0.05) in both groups in fasting blood glucose (FPG). Saxagliptin group showed insignificant decrease in body weight by whereas glimepiride group showed significant increase in body weight. The addition of Saxagliptin to ongoing Metformin monotherapy provided significant HbA1c-lowering efficacy after at least 12 weeks of treatment compared with the addition of Glimepiride.
Authors and Affiliations
Mu’tazbellah F. Alzubi, Amal S. Aljariri, Deema A. Gawgneh, Ola A. Aldmour, Niveen A. Alabbadi, Hayat Y. Hilan
Keywords
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