Screening of Anti-inflammatory Effect of Venlafaxine in Wistar Albino Rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Abstract: The aim is to evaluation of anti-inflammatory effect of Venlafaxine in Wistar Albino Rats.Wistar Albino rats were used in the study. Total 18 rats were divided into three groups each of 6 rats. G-A (Control), G-B- Aspirin (300 mg/kg) and G-C (Venlafaxine (50 mg/kg). All the drugs given 30 min before induction of paw inflammation by Carrageenan. Data was expressed by MEAN±SD and percentage (%). SPSS software was used for statistical analysis of data.Rats treated with standard and test drug showed significant difference compared to control group. Aspirin showed significant anti-inflammatory effect compared to Venlafaxine group. Similar results were observed in percentage of inflammation and reduction in percentage of inflammation. Venlafaxine produced anti-inflammatory action in paw model in rats. The anti-inflammatory effect of test drug is similar to Aspirin. Keywords:Anti-inflammatory,Aspirin, Carrageenan, Paw edema, Percentage of inhibition, Venlafaxine
Authors and Affiliations
Ganesh V, Mohamed Gani A, Sandeep V, SarathBabu K
Keywords
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