Screening of Lactate dehydrogenasein ascitic/pleural fluid in Saraswathi institute of Medical Sciences, Hapur
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Introduction: Aims To investigate lactate dehydrogenase (LDH) measurements in fluids.These are more sensitive and specific markers for differentiating between exudates and transudates, as confirmed clinically, than the measurement of fluid total protein concentrations alone. Materials and Method: The study was conducted in the department of medicine and department of biochemistry at Saraswathi institute of medical sciences. Pleural fluid, and ascitic fluid from patients were analysed retrospectively for LDH, cholesterol, and total protein. Clinical classification of transudate or exudate was reached independently by reviewing clinical details and laboratory data. Observation and Result: Estimating the Fluid Lactate Dehydrogenase levels in patients presenting with ascites helps in differentiating between malignant and non malignant effusion. It is highly sensitive (100%) and highly specific (100%). Estimating the Fluid Lactate Dehydrogenase level in patients presenting with pleural effusion helps in differentiating between transudative and exudative effusion. It is highly sensitive (100%) and highly specific (100%). Conclusion: Biochemical analysis of LDH in ascitic fluid helps in differentiating malignant and non-malignant etiology (Negative Predictive Value = 100%, confidence interval= 75.3-100%). Biochemical analysis of F.LDH (Ascitic Fluid)/ S. LDH helps in differentiating malignant and non-malignant etiology (Negative Predictive Value = 100%, confidence interval = 75.3-100%).
Authors and Affiliations
Dr. Ashish Saran, Dr Ankit Tyagi, dr Anil Kumar Kem
Keywords
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- EP ID EP423862
- DOI 10.9790/0853-1712072429.
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