Screening of the Drug Sumatriptan for Its Antiinflammatory Potential in Albino Rats
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2014, Vol 9, Issue 1
Abstract
Objective: To study the anti-inflammatory activity of sumatriptan in acute and sub acute experimental animal model. Methods: Adult albino rats of either sex weighing 150-200 grams were randomly divided into 3 groups of 6 each. The control, standard and test group received Gum acacia 2g%, indomethacin 10 mg/kg and sumatriptan 1.28 mg /kg respectively .Acute inflammatory activity was assessed by carageenan induced paw oedema, Turpentine induced arthritis model and sub acute activity was assessed by cotton pellet induced granuloma model. Results: The anti-inflammatory activity was expressed as percentage of inhibition. In carageenan induced paw oedema, percentage of inhibition of paw oedema by indomethacin and sumatriptan respect to control were 51%and25% respectively. Hence the anti-edema effect of the test group was good and comparable with standard.The percentage of inhibition of paw oedema by the test group considering the percentage of inhibition of standard as 100 % was 65.5%.Thus sumatriptan showed good anti-inflammatory activity compared with the standard drug indomethacin in carageenan induced rat paw oedema model. The percentage of inhibition of knee arthritis with respect to control by standard and sumatriptan were 60% and 23%respectively.Hence the test group showed moderate antiarthritic effect in comparision to indomethacin .The percentage of inhibition of knee arthritis by the test group considering the percentage of inhibition of standard as 100% was 52.3%.Thus sumatriptan showed anti-inflammatory activity of moderate degree compared with the standard drug indomethacin in Turpentine induced arthritis animal model. The percentage of inhibition of granuloma. by standard and sumatriptan were49% and 13%respectively.The antigranuloma effect of test group was good as compared with standard.The percentage of inhibition of dry granulation tissue of the test group considering the percentage inhibition of standard as 100% was 58.2%.Thus sumatriptan shows moderate anti-inflammatory effect compared with the standard drug indomethacin in cotton pellet induced granuloma animal model. Conclusion: As sumatriptan showed considerably good antiinflammatory effect in acute models and in sub acute model ,it can be used as a promising antiinflammatory agent .
Authors and Affiliations
Brahadeesh M , Suresha R. N , Satish A. M
Keywords
Related Articles
- EP ID EP99554
- DOI -
- Views 115
- Downloads 0
Evaluation of lumbar transforaminal epidural steroid injection by infraneural route
Conservative treatment of Lumbosacral radiculopathy mainly includes Transforaminal epidural steroid injection which delivers the inject ate directly to anterior epidural space, thus giving the nerve root a better relief...
Surgical management of galeazzi fracture dislocation
: By definition, Galeazzi fracture involves fracture of the shaft of radius anywhere between radial tuberosity and a point 2-4 cms proximal to the wrist, associated with sub luxation or dislocation of lower end of ulna....
Removal of Large Foreign Body in the Bronchus by an Unusual Method
Anaesthesia for bronchoscopy is challenging in paediatric patients as the airways are narrower and desaturation is faster compared to adults. Life threatening intra operative complications may lead to significant morbidi...
Anaesthetic Implications in Obese Patients: A Case Series
Across the globe, obesity is a major cause for post-op morbidity and mortality. More people are obese than malnourished, and its second only to smoking as a preventable cause of death. Obesity is defined as BMI>30kg/m...
Anticoagulant Induced Pseudothrombocytopenia- An Incidental Finding
Thrombocytopenia may be caused either by impaired platelet production or due to accelerated platelet destruction. In some cases, there is an erroneously low reading of platelet counts in the automated analyzers, without...