SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM
Journal Title: Pharma Science Monitor-An International Journal Pharmaceutical Sciences - Year 2010, Vol 1, Issue 2
Abstract
Oral route has always been preferred route for formulators and has dominated over other routes of administrations. However this preferred route is limited to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Approximately 40%of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. The oral bioavailability of poorly water soluble drugs may be enhanced when coadministered with meal rich in fat has led to increasing recent interest in the formulation of poorly water soluble drugs in lipids. Also nowadays much attention has been paid to the lipid based formulations. Some examples of marketed lipid based formulations are Sandimmune Neoral (Cyclosporine A), Novartis Pvt. Ltd. and Fortovase (Saquinavir), Roche Laboratories Inc. with much attention focused on self micro-emulsifying drug delivery systems (SMEDDS). Self micro emulsifying drug delivery systems are isotropic mixtures of oil, surfactant, co-surfactant and drug with a unique ability to form fine oil in water microemulsion upon mild agitation following dilution with aqueous phase. The hypothesis behind dissolution rate enhancement with SMEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized form, and the small size of the formed droplet provides a large interfacial surface area for drug absorption. This article gives a complete overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble molecules.
Authors and Affiliations
Shukla Jill B. * , Koli Akshay R , Ranch Ketan M , Parikh Rajesh K
Keywords
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