Semi Solid dosage Forms Manufacturing: Tools, Critical Process Parameters, Strategies, Optimization and Validation
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 2
Abstract
The objective of present study was to document the requirements for manufacturing of semisolid dosage forms. These guidelines also brief about some issues associated with tools, strategies, critical process parameters and strategies of the manufacturing and validation processes specific to semisolid dosage forms. Studies about the effect of manufacturing processes and formulation excipients on the rheology of semisolids have contributed significantly toward their characterization. The development of computer-assisted instruments also has contributed substantially to their characterization and thereby to improving their quality. Moreover, some of the guidelines established by regulatory agencies, especially by FDA, are major steps toward the standardization of these dosage forms. Variations in the manufacturing procedure that occur after either of these events are likely to be critical to the characteristics of the finished product. This is especially true of any process intended to increase the degree of dispersion through reducing droplet or particle size (e.g., homogenization). Keywords: Process, Tools, Parameters, Validation
Authors and Affiliations
Pharm Nwoko Valentine. E
Keywords
Related Articles
- EP ID EP377641
- DOI -
- Views 150
- Downloads 1
Pharmacological evaluation of extract of Lannea coromandelica(Linn) for its anti-ulcer activity in rodents
Peptic ulcer disease (PUD) encompassing gastric and duodenal ulcer is the most prevalent gastro intestinal disorder the pathophysiology of PUD involves imbalance between an offensive (acid, pepsin, H . pylori) and defe...
Formulation and Invitro evaluation of β-cyclodextrin based Nanosponges
In the present study Nanosponges were prepared by solvent evaporation method employing Β-Cyclodextrin and HP β-cyclodextrin as a polymer. Gliplizide is taken as model drug for studying various formulations of cyclodextri...
Is There a Relationship Between Bupropion Plasma Levels and Blood Pressure Increase?
Bupropion is largely used as an antidepressant and smoking cessation therapy. The aim of this work was to evaluate effects of increased bupropion plasma levels on blood pressure and heart rate in patients with depression...
Event Monitoring in Patients Prescribed with Anti-tubercular Therapy
Tuberculosis is a chronic, granulomatous infectious disease caused by Mycobacterium tuberculosis. Multi-drug resistance is a chronic problem associated with treatment of tuberculosis where a substantial proportion of tub...
Alternative Treatment of Methicillin Resistant Staphylococcus aureus Infections: An Update
Abstract: Vancomycin has been a predominant treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections for decades. Due to the resurgence of some resistant and intermediate strains to vancomycin, it is n...