Seroprevalence of HIV, Hepatitis B and C Viruses in Patients with Haematological Malignancies in Lagos
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Backgound: Haematological malignancies are often associated with immunosuppression as a result of the disease and/or chemotherapy. This increases the risk of infections by pathogens as well as the reactivation of latent infections which may be associated with adverse prognosis. Hepatotrophic viruses may be reactivated in subjects with haematological malignancies. Objectives: To determine the seroprevalence of hepatitis B and C in patients with haematological malignancies. Methods: This is a hospital based case control study. Consecutive subjects with haematological malignancies were recruited into the study through the haematology clinics/wards while blood donors were recruited as controls from the donor clinic. Samples of study participants were screened Hepatitis B surface Antigen (HBsAg), Hepatitis B core antibody (HBcAb), Hepatitis B envelope Antigen (HBeAg) and Antibodies to Hepatitis C virus using ELISA based assay. Results were analyzed using SPSS version 11. Chi square, Fishers Exact test and student’s T-test were used where appropriate to compare results between groups. P value < 0.05 was considered significant.RESULTS: Eighty-eight subjects were recruited into the study comprising 42 patients with haematological malignancies and 46 apparently healthy blood donors. Frequency of HBsAg for the patients group (14.3%) was not significantly different from 21.3% for the control group P>0.05. Two of the study subjects were positive for HBeAg. There was no significant difference in the seroprevalence of HBcAb between both groups (P= 0.68). CONCLUSIONS: This study suggest that there is no significant difference in the seroprevalence of HbsAg, HBcAb and anti-HCV antibodies in both study groups however patients with hematological malignancies are at increased risk of reactivation or developing active disease
Authors and Affiliations
Asuquo M Inyama, Akanmu A S, Nwogoh B, Ibanga I A, Durosinmi M A
Keywords
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- EP ID EP250807
- DOI 10.9790/0853-1612069397
- Views 79
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