Seroprevalence of TORCH Infections in Pregnant Women with Bad Obstetric History in and Around Bikaner, Northern Western Rajasthan
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 5
Abstract
Abstract: The infections which are caused by Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV) and the Herpes Simplex Virus (HSV-2) during pregnancy are often associated with adverse foetal outcomes and reproductive failures. In the Indian context, the exact seroprevalence of these infections is not known due to unavailability of baseline data. TORCH infections are initially in apparent or asymptomatic and are thus difficult to diagnose on clinical grounds. The main aim of this study to detect specific IgM and IgG antibodies for Toxoplasma, Rubella, Cytomegalovirus and Herpes Simplex virus 2 by Enzyme Linked Immunosorbent Assay Test and also to know the outcome of TORCH infection in pregnant women with bad obstetric history in Bikaner region. Over a two-year period 75 serum samples were collected from pregnant women having bad obstetric history, attending Department of Obstetrics and Gynaecology department, P.B.M. hospital, Bikaner during the period of jan.2015 to feb.2017. IgM and IgG Anti TORCH antibodies were detected from serum by micro capture ELISA test kit in Department of Microbiology and Immunology, Sardar Patel Medical College,Bikaner. In the present study of 75 women with BOH, seropositivity of different TORCH agents (IgG and IgM) was Toxoplasma gondii 5.33% and 2.66%, Rubella was 84% and 6.66%, CMV was 82.66% and 9.33% and HSV was 38.66% and 8% respectively indicating recent infection which was maximum in CMV, HSV, Rubella and Toxoplasma gondii. The maximum number of 45 cases (60%) was of the age group 21-25 years followed by 20 cases (26.66%) 26-30 years age group, 05 cases (6.66%) 31-35 years age group, 03 cases (4%) 36-40 years age group and 02 cases (2.66%) in 16-20 years age group. The observations can be interpreted as incidence and prevalence indicating highest incidence of CMV followed by HSV, Rubella and Toxoplasmosis. The prevalence of Rubella was found highest followed by CMV, HSV and Toxoplasmosis. In conclusion this study has established that TORCH infection play an important role in adverse fetal outcome in pregnant women. Therefore, all the antenatal cases should be routinely screened for the TORCH infections, for carrying out early interventions to prevent foetal loss.
Authors and Affiliations
Dr. Ravindra Kumar, Dr. Abhishek Binnani, Dr. Sachin Shyoran
Keywords
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