Serum CA19–9 Levels and Pancreatic Beta Cell Destruction in Type 2 Diabetes Mellitus Patients
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 14, Issue 6
Abstract
Carbohydrate antigen 19–9 (CA 19–9) is a tumor–associated antigen, which is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes. The aim of this study was to evaluate serum CA19–9 levels in patients with type 2 diabetes mellitus (T2DM) in comparison with age– and gender matched control subjects. The study was carried out on 90 patients having T2DM and 90 subjects as control group, with respect to diabetes duration and estimation of lipase, triacylglycerol(TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), glycated hemoglobin (HbA1c) levels and serum CA 19–9 levels. Abdominal computed tomography (CT) scan was performed in order to differenciate subjects having abdominal malignancy either from diabetic or control groups. The mean values of CA 19–9 levels were 24.3±12.3 and 6.5±3.3 U/ml for diabetic patients and control group, respectively (p < 0.001). It is proposed that a higher cutoff value of CA 19–9 than 57.14 U/ml may be used to differentiate between benign and malignant pancreatic disease in diabetics. In addition, subtle elevations of CA 19–9 in diabetics may be considered as indicator of exocrine pancreatic dysfunction.
Authors and Affiliations
Mohammad Mansour Saleh Saif, Waddaah M. Al-Asbahy, Abdulkawi Ali Al-Fakih, Adeeb Mohammed Albadani
Keywords
Related Articles
- EP ID EP342362
- DOI 10.9734/BJPR/2016/30808
- Views 66
- Downloads 0
β(1-3)(1-6)-D-glucans Modulate Immune Status and Blood Glucose Levels in Dogs
Aims: The objective of this study is to evaluate the effects of adding two different glucans coded as BGO1 and BGO2 into commercial feed of dogs. Study Design: We measured changes in phagocytosis, levels of IL-2 in bloo...
Synergistic Activity of the Antibiotic Meropenem in Combination with Edible Mushroom Extracts against Multidrug Resistant Bacteria
Aims: The objective of this study was to evaluate the antibacterial potency of meropenem in synergism with five edible mushroom extracts against multidrug resistant clinical isolates. Methodology: Minimum Inhibitory Con...
Evaluation of Antioxidant and Antiacne Activity of Psorospermum febrifugum (Spach) and Psorospermum corymbiferum (Hochr.)
Aim: This study investigated the anti-acne activity, lipase inhibitory effects and antioxidant property of Psorospermum febrifugum and Psorospermum corymbiferum of the family Hypericaceae. Study Design: Antimicrobial as...
Anti-Mycobacterium Metabolite from Marine Sponge Iricinia fusca
Chemical investigation of the marine sponge Ircinia fusca leads to isolation of a new pyrrole derivative (1) and two known compounds namely, 3 methyl decanoic acid (2) and Benzenedicarboxylic acid (3). The structures of...
In vitro Antisalmonellal and Antioxidant Properties of Mangifera indica L. Stem Bark Crude Extracts and Fractions
Aims: Typhoid fever is still a major public health problem in developing countries, where it remains endemic. In view of searching for new antityphoid substances, the antisalmonellal and antioxidant properties of extract...