Serum Concentration of Immunoglobulin Classes and Subclasses in Macedonian Elderly People
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2012, Vol 5, Issue 2
Abstract
Aim: The aim of this study was to determine the serum concentrations of immunoglobulin classes (IgA, IgM and IgG) and subclasses (IgG1, IgG2, IgG3 and IgG4) in elderly individuals from the Republic of Macedonia. Material and Methods: This study included elderly persons from the Gerontology Department “13 Noemvriâ€, Skopje, Republic of Macedonia between the ages of 65 and 101 years, previously screened with the SENIEUR protocol. We investigated the serum concentration of immunoglobulin classes (IgA, IgM and IgG) and subclasses (IgG1, IgG2, IgG3 and IgG4) in these two groups by immunonephelometry. Results: The results have shown significantly higher concentration in the NON-SENIEUR group for the IgA, IgG, IgG1, and IgG2. Serum concentration of immunoglobulin classes and subclasses in the SENIEUR group have shown significantly higher values in males for IgG, IgG1, and IgG2 and in the NON-SENIEUR group significantly higher values in females for IgG, and IgG1. Conclusion: Macedonian elderly people from NON-SENIEUR group have shown significantly higher serum concentration of IgA, IgG, IgG1, and IgG2 but without differences in IgM, IgG3 and IgG4. There was gender difference in the serum immunoglobulin concentration between SENIOUR and NONSENIOR elderly group.
Authors and Affiliations
Meri Kirijas| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia, Slavica Hristomanova| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia, Dejan Trajkov| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia, Milanka Pajkovska| Gerontology Department “13 Noemvri”, Skopje, Republic of Macedonia, Berislav Kostov| Gerontology Department “13 Noemvri”, Skopje, Republic of Macedonia, Mirko Spiroski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia
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- EP ID EP8860
- DOI 10.3889/MJMS.1857-5773.2012.0248
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