Serum Creatinine Kinase – An Alternative Diagnostic Marker In Ruptured Tubal Pregnancy In Women Attending A Tertiary Care Hospital In North India
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 5
Abstract
Introduction: Ectopic pregnancy is the pregnancy outside the uterine cavity with incidence of 1% of pregnancy. Current diagnosis in the hemodynamically stable patient is based on the reliability of 2-D ultrasound (USG) and quantitative levels of β-Human Chorionic Gonadotropin (β-hCG). In tubal pregnancy, the zygote penetrates the tubal epithelium and lies next to the muscular layer as the fallopian tube lacks a sub mucosal layer. This invasion into the muscle causes an increase in muscle cell creatinine kinase (CK) in blood. Aim and objective: To evaluate the role of serum creatinine kinase (CK) as a biochemical marker in the diagnosis of ruptured tubal pregnancy. Materials and methods: A prospective study was carried out on 30 women with first trimester pregnancy. Group A (n=15) with features suggestive of ruptured tubal pregnancy formed the study group and group B (n=15) with normal intrauterine pregnancy were taken as controls. CK levels in the two groups were compared. Results: In tubal pregnancy, the serum CK levels (90.1 ± 31.93 IU/L) were higher than those in normal intrauterine pregnancy (46.3 ± 20.15 IU/L). Conclusion: Serum CK values appear to be a useful marker in the diagnosis of ruptured tubal pregnancy.
Authors and Affiliations
Farhat Ali Lone
Keywords
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