Serum gamma glutamyl transferase and hs-CRP levels in patients with type 2 diabetes mellitus
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 4
Abstract
Introduction: Type 2 diabetes mellitus and its complications is an important health problem. As oxidative stress and inflammation appears to play a major role in the pathogenesis of diabetes mellitus and development of its complications; we intend to study the serum GGT activity and hs- CRP levels in type 2 diabetes mellitus without complications, type 2diabetes with complications and age and sex matched normal controls. Materials and Methods: Study consisted of 75 subjects out of whom 25 subjects were type 2 diabetics without any complications, 25 subjects were type 2 diabetics with complications and 25 were age and sex matched normal controls. Serum GGT, serum hsCRP, FBS and glycated hemoglobin were measured in these subjects. Results: Levels of serum hs- CRP and GGT is increased in type 2 diabetics without any complications and type 2 diabetics with complications, when compared to controls, which was statistically significant (p < 0.001). Conclusion: Present study showed increase in the levels of hs- CRP and GGT levels in type 2 diabetics without complications and type 2 diabetics with complications when compared to healthy controls. These findings provide evidence that oxidative stress and inflammation plays a role in the pathogenesis of diabetes mellitus and development of its complications.
Authors and Affiliations
Srinidhi Rai, Tirthal Rai, Swetapadma Nayak, Prajna K
Keywords
Related Articles
- EP ID EP243126
- DOI -
- Views 91
- Downloads 0
Prevalence of metabolic syndrome in obese medical students –a case control study
Introduction: The Metabolic Syndrome is a constellation of risk factors predictive of future Cardio Vascular Accidents (CVA) and Type 2 Diabetes Mellitus (T2DM) in adults. Recently several studies revealed that metabolic...
Association of Vitamin D levels and Cognitive function in Postmenopausal women
Background: Vitamin D deficiency(VDD) is a major health concern in India, especially in elderly individuals and is adversely associated with neurocognitive function. Aims and Objectives: 1. To assess the 25hydro...
Application of failure mode and effects analysis to minimize quality failures in clinical biochemistry laboratory
Introduction Quality failures in the clinical laboratories should be analyzed to improve patient safety in hospital Purpose of this study is to apply failure mode and effects analysis FMEA for prospective risks of qualit...
Evaluation of microalbuminuria in non-diabetic and non-hypertensive patients with acute myocardial infarction
Introduction: Microalbuminuria is defined as the excretion of 30to 300mg of albumin per day in urine. It is frequently present and a known cardiovascular risk indicator in diabetic populations, in hypertensive and genera...
Oxidative stress and antioxidant status in coronary artery disease patients before percutaneous transluminal coronary angioplasty
Introduction: Oxidant lead to cell death through apoptosis and necrosis. The effects of reactive oxygen radicals are balanced by the antioxidant action. The aim of the study was to assess oxidative stress and antioxidant...