Serum Homocysteine Levels in Various Stages of Chronic Kidney Disease
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 3
Abstract
Objectives: To study serum homocysteine levels in Chronic Kidney Disease (CKD) patients and co-relate it with the stages of CKD, Body Mass Index (BMI), cholesterol levels and cardiac function and to study effect of hemodialysis on homocysteine levels. Settings & Design: Cross sectional study carried out at a tertiary care teaching hospital. Methods: Thirty CKD patients as cases and 30 normal subjects as controls were randomly selected according to eligibility criteria. Clinical examination, blood investigations including serum homocysteine levels and 2D-ECHO were done for all patients. Data was analyzed using Mean, Standard Deviation and Test of Significance for quantitative data. Results: Serum Homocysteine levels were significantly higher in 90% CKD patients as compared to non CKD group (P<0.01). Duration of CKD > 2 years was associated with higher serum homocysteine levels as compared to lesser duration (P<0.05). Serum homocysteine levels were higher with advanced stages of CKD, but it was not statistically significant (P>0.05). Other results that were not statistically significant were - Homocysteine levels were higher in nondialysed patient as compared to dialysed patients (P>0.05), Homocysteine levels were low in patients on hemodialysis with high flux dialyser compared to low flux dialyser, Homocysteine levels were not affected by BMI ( P>0.05) and CKD patients with high homocysteine levels had high cholesterol ( P>0.05)and lower Ejection fraction.(P>0.05). Conclusions: Serum Homocysteine levels are high in CKD patients and its level increases with duration of CKD.
Authors and Affiliations
Kalpana S. Mehta, Sandip P. Bhurke, Suyash V. Sharma
Keywords
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- EP ID EP547804
- DOI 10.21276/ijmrp.2017.3.3.022
- Views 99
- Downloads 0
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