Induction of Ovulation in Primary Infertility: A Prospective Study
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 6
Abstract
Background: Until the middle of last century, infertility was only a diagnosis with a very little or no hope of treatment. This study was done to compare the ovulation rate and pregnancy rate between patients treated with clomiphene citrate alone and those treated with clomiphene citrate along with single dose of urinary FSH (uFSH) (75 IU). Methods: A prospective, randomized study was carried out on 50 patient of primary infertility attending Department of Obs. and Gynae, NIMS. Medical College, Jaipur from January 2017 to September 2017. Patients were allocated to two groups at random. Group A: Patients in this group were administered clomiphene citrate in a dose 50-100 mg per day from days 3-7 of menstrual cycle. Group B: Were given clomiphene citrate 50-100 mg. per day from days 3-7 of menstrual cycle along with single dose of urinary FSH (uFSH) 75 IU on 3rd day of menstrual cycle. The cases were simultaneously monitored by Ultrasonography, Basal Body Temperature (BBT) record and cervical mucus study. Results: The single dose of Urinary FSH (uFSH) on 3rd day when used with clomiphene citrate from 3rd to 7th day menstrual cycle is better regimen for ovulation induction as well as for conception as compared to clomiphene citrate alone. This combination is simple to use and cheap. The risk of ovarian hyperstimulation syndrome (OHSS) is avoided because of controlled ovarian stimulation. This exogenously administered FSH compensates adverse effects of clomiphene citrate induced increase in LH and this FSH also promotes good follicular growth and recruitment hence the chances of ovulation as well as conception is increased. More and more estradiol is also generated within the growing follicles which provides favorable uterine environment to fertilized ovum. Conclusion: The single dose of Urinary FSH (uFSH) on 3rd day when used with clomiphene citrate from 3rd to 7th day menstrual cycle is better regimen for ovulation induction as well as for conception as compared to clomiphene citrate alone.
Authors and Affiliations
Poonam Bhojwani, Dr. Sonal, Gajendra Singh Verma, Shagun Gupta`
Keywords
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- EP ID EP548777
- DOI 10.21276/ijmrp.2017.3.6.041
- Views 96
- Downloads 0
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