Serum Human Chorionic Gonadotropin Level in Pre-Eclamptic and Normotensive Pregnant Women: A Prospective Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 8
Abstract
Introduction: Pre-eclampsia causes the various fetal and maternal complications. Can cause 8-10% maternal deaths in india and 5-10% in western countries. Human Chorionic Gonadotropin is composed of alfa and beta subunit, beta being specific to HCG. Intact Serum HCG molecule can be detected 7-9 days after LH surge, levels double every 2 days, maximum at 8-10 weeks, Peak levels (100000 mIU/ml) 60th -80th day after last menses, decreases from 10-12 weeks, nadir is reached by 20 weeks which remains unchanged till delivery. Material and Methods: 70 women enrolled. (1) Study group: 50 pre-eclamptics at 20 or > weeks. (2) Control: 20 Normotensive, same gestation. Data collected, investigations done. Serum HCG Quantitative test, based on ENZYMELinked Immuno Sorbent Assay (ELISA) Results: Mean HCG level, Study group (29621.8mIU/ ml), Control (11O59.3mIU/ml) p value <0.001 (HS). Mean HCG levels were higher in severe (38916.48mIU/ml) than mild (16786.29mIU/ml) preeclampsia, p value <0.001(HS). Difference in Serum HCG was not significant between control (11059.3mIU/ml+-) and mild pre-eclampsia (16786.286 mIU/ ml+-). Significant difference found between Serum HCG in control (11059.3mIU/ml)and Severe Preeclampsia (38916.48 +/-mIU/ml). Conclusion: Serum HCG significantly increased in preeclamptics than normotensive patients. Difference was larger between severe pre-eclamptic and normotensive pregnants than mild pre-eclamptic and normotensives. HCG is better predictor of severity.
Authors and Affiliations
Balwinder Kaur, Chittranjan Vij, Manjit Mohi
Keywords
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