SIMULTANEOUS DETERMINATION OF ANAESTHETIC AND ANTIBOTIC IN FLUID BY ELECTOCHEMILUMINESCENCE COUPLING CAPILLARY ELECTROPHORESIS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 4
Abstract
The coupling of electrochemiluminescence (ECL) with capillary electrophoresis (CE) was developed for the simultaneous determination of lidocaine and lomefloxacin in human urine. Under the optimized conditions: ECL detection at 1.15V, 20mM phosphate buffer at pH 6.7, 5mM Ru(bpy)3 2+ and 60mM phosphate buffer at pH 7.6 in the detection reservoir, detection limits of 0.02ug mL-1 for lidocaine and 0.06ug mL-1 for lomefloxacin were obtained. Relative standard derivations of the ECL intensity and the migration time were 3.5 and 1.1% for 6ug mL-1 lidocaine, 3.2% and 3.7% and 1.2% for 6ug mL-1 lomefloxacin, respectively. Developed method was successfully applied to determine the amounts of lidocaine and lomefloxacin in human urine. A baseline separation for lodocaine, proline and lomefloxacin was achieved within 10 mins.
Authors and Affiliations
Su Ming
Keywords
Related Articles
- EP ID EP622523
- DOI -
- Views 146
- Downloads 0
EFFECT OF FUNCTIONAL SEEDS MIXTURE ON GLUCOSE AND LIPID PROFILE
Introduction: Elevation of blood glucose, cholesterol and low-density lipoprotein have adverse effects on blood vessels, heart, and health. There is evidence to use natural functional food instead of medicine to control...
DISPOSAL OF DEAD BIRDS AND MANURE IN POULTRY FARMS UNDER DIFFERENT PRODUCTION AND MANAGEMENT SYSTEMS IN KHARTOUM STATE, SUDAN
This study was conducted between Dec 2015 and Jan 2018 during dry and wet seasons in two consecutive years with the objective of evaluating the disposal of manure and dead birds in poultry farms located in Khartoum State...
THE STUDY OF TRIPLE AND QUADRUPLE ANTITUBERCULOUS DRUG THERAPY INDUCED HEPATOTOXICITY
It istheoreticalanalysis of the hepatotoxicity induced by antituberculosis drug therapies. The most commonly used therapies for tuberculosis are triple and quadruple antituberculosis drug therapy. We analyse by theoretic...
HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES 0F CARICA PAPAYA FRUITS IN STREPTOZOTOCIN INDUCED DIABETIC MICE
Diabetes mellitus (DM) is a systemic metabolic disorders with several major health complications affecting both the quality and the length of life. The purpose of this study is to appraise the antidiabetic and antihyperl...
PREMATURE EVENTS IN CHIKUNGUNYA VIRUS INFECTION AND THEIR INHIBITING STRATEGIES—FROM VIRUS CELL BINDING TO MEMBRANE FUSION
Chikungunya virus is a rapidly emerging mosquito-borne alphavirus causing millions of infections in the tropical and subtropical regions of the world. This infection often leads to an acute self-limited febrile illness w...