Simvastatin inhibits the increase in serum tau protein levels in the acute phase of ischemic stroke.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 6
Abstract
Our goal was to analyze the effects of treatment with a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (simvastatin, 40 mg/day) on serum S100BB and tau protein levels during the acute ischemic stroke (IS). Twenty four patients with IS were divided into two equal groups; treated and untreated with simvastatin. Blood was obtained four times during acute IS. Tau protein was noticed in six patients from treated group and in five patients from untreated group. The serum tau protein levels significantly increased on the 10th day only in patients untreated with simvastatin (p < 0.05). Simvastatin did not exert an effect on serum S100BB protein levels.
Authors and Affiliations
Jacek Kurzepa, Joanna Bielewicz, Halina Bartosik-Psujek, Anna Szczepańska-Szerej, Zbigniew Stelmasiak
Keywords
Related Articles
- EP ID EP91472
- DOI -
- Views 64
- Downloads 0
Different effects of nitric oxide synthase inhibitors on convulsions induced by nicotine in mice.
Acute intraperitoneal (ip) administration of N(G)-nitro-L-arginine (NNA, 10, 20 and 40 mg/kg), a non-selective nitric oxide synthase (NOS) inhibitor, significantly and dose-dependently decreased the incidence of convulsi...
Drug-induced myopathies. An overview of the possible mechanisms.
Myopathy is usually a non-fatal muscle disease involving skeletal muscle weakness, tenderness and pain with the possibility of the plasma creatinine kinase elevation. There are many different types of myopathies, some of...
Pharmacokinetics and metabolism of nicotine.
Nicotine (NIC), the major constituent of tobacco, is responsible for the compulsive use of tobacco. Advances in understanding of the pharmacokinetics and metabolism of NIC have been made rapidly over the past decade. The...
Inflammatory lipid mediators in ischemic retinopathy.
Ischemic proliferative retinopathy develops in various retinal disorders, including retinal vein occlusion, diabetic retinopathy and retinopathy of prematurity. Ischemic retinopathy remains a common cause of visual impai...
Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state.
Background: The biological effects and health implications of electromagnetic field (EMF) associated with cellular mobile telephones and related wireless systems and devices have become a focus of international scientifi...