“SOLID AS SOLVENT”: NOVEL SPECTROPHOTOMETRIC ANALYTICAL TECHNIQUE FOR QUANTITATIVE ESTIMATION OF TINIDAZOLE IN TABLETS USING SOLIDS (EUTECTIC LIQUID OF PHENOL AND LIGNOCAINE HYDROCHLORIDE) AS SOLUBILIZING AGENTS (MIXED SOLVENCY CONCEPT)
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 3
Abstract
As per the mixed solvency concept, every substance present in this universe has got solubilizing power. The substance may be a gas, liquid or solid. The present research work is an attempt to demonstrate the solubilizing property of solids. Also, the present research work is one of the examples which prove that solids can also be employed for spectrophotometric analysis of poorly soluble drugs in place of organic solvents. Tinidazole has got poor solubility in distilled water, while, significantly high solubility in a eutectic liquid of two solids, namely, phenol and lignocaine hydrochloride. Phenol and lignocaine hydrochloride were employed in 4:1 ratio to give eutectic liquid (PL 41). This eutectic liquid was employed to act as solvent to extract out the drug, tinidazole, from the fine powder of its tablets for spectrophotometric estimation at 318 nm. Necessary dilutions were done using distilled water. The solubility of tinidazole in distilled water is 5.38 mg/ml at room temperature while the approximate solubility in PL 41 is more than 200 mg/ml. Proposed method is novel, accurate, rapid and free from toxicity of organic solvents and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the analytical method employed. Tablet excipients together with phenol and lignocaine hydrochloride did not interfere at 318 nm.
Authors and Affiliations
Rajesh K Maheshwari
Keywords
Related Articles
- EP ID EP295556
- DOI 10.22270/jddt.v7i3.1437
- Views 104
- Downloads 0
The Traditional Approaches for the Management of Mental Diseases W.S.R. to Indigenous Herbs in Manovikara
The uses of ayurveda not only reside around as main stream of ancient science but it also served as complementary or alternate medicine. Ayurveda provides principles to maintain good healthy status of mind, body and soul...
An updated review on Anti-Alzheimer’s herbal drugs
Alzheimer’s disease (AD) is related to cognitive impairment, dementia observed generally in aged population due to neurodegeneration in an ongoing manner. It gradually worsens memory power of the patient. The hallmark di...
DESIGN, SYNTHESIS AND DOCKING STUDY OF PYRIDINE DERIVATIVE FOR ANTIDEPRESSANT ACTIVITY
On the basis of literature survey compound 2-(1H-benzo[d]imidazole-1-yl)-N-(3-cyano-4,6-diphenylpyridin-2-yl) acetamide (6) was designed. Compound 6 and imipramine were virtually studied for their antidepressant activity...
VALIDATED RP HPLC METHOD DEVELOPMENT FOR EXEMESTANE IN TABLET DOSAGE FORM
The aim of this present work was to develop stability indicating LC method, which is selective, accurate, simple, precise, reliable, cost effective and rapid for the quantification of all possible degradants and determin...
IDENTIFICATION OF BIOLOGICAL COMPONENTS FROM POTENTIAL BONE HEALER MEDICINAL PLANTS
Nature has been a wellspring of therapeutic for a vast number of years and a great number of present day drugs have been separated from plant resources. It has been evaluated that natural prescriptions serve around 80% o...