SOLUBILITY ENHANCEMENT OF INDOMETHACIN BY SOLID DISPERSION TECHNIQUE AND DEVELOPMENT OF FAST DISSOLVING TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
Solid dispersion had become a potential candidate to overcome the poor solubility of drugs. The aim of the present study was to prepare and compare the dissolution profiles of pure indomethacin and its solid dispersions using PEG4000 and Gelucire 50/13 as carriers and development of FDTs. The solid dispersions were prepared by Melting method. The prepared SDs was subjected to solubility studies in pH 6.8 phosphate buffer. Drug content and dissolution studies of the prepared SDs and PMs were performed and quantification was done by UV/VIS spectrophotometric method at the absorption maximum 320 nm. The prepared SDs was characterized by FT-IR and DSC. Formulation F3 was selected for the Preperation of FDTs because of its maximum solubility, dissolution rates and appearance. Indomethacin FDTs were prepared by direct compression method, using various superdisintegrants croscarmellose, kyron and Indion. Pre-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index and hausner ratio were carried out to study the flow properties of prepared blend to achieve uniformity of tablet weight and the values were within the limits., post-compression studies for the prepared tablets like hardness, weight variation, friability, drug content, wetting time, water absorption ratio, and in vitro disintegration time, in vitro dissolution profiles were performed., results obtained were satisfactory. Formulation T7 containing croscarmellose as superdisintegrant had shown the disintegration within 23 sec and highest release rate of 94.68% at the end of 15 min.
Authors and Affiliations
Raja Janamala , Rajashekar Valluru , Anusha Thudi, Jagadish Devisetty , K. A Sridhar
Keywords
Related Articles
- EP ID EP135495
- DOI -
- Views 113
- Downloads 0
EVALUATION OF ANTIMICROBIAL ACTIVITY AND PRELIMINARY PHYTO-CHEMICAL STUDIES ON WHOLE PLANT OF STACHYTARPHETA JAMAICENSIS (L.)VAHL
The antimicrobial activity and preliminary phyto-chemical studies on whole plant of Stachytarpheta jamaicensis were evaluated. The shade dried and coarsely powdered plant was successively extracted with n-hexane, chloro...
ANTIOXIDANT ACTIVITY OF POLYGALA ROSMARINIFOLIA WIGHT& ARN WHOLE PLANT IN ALLOXAN INDUCED DIABETIC RATS
Administration of ethanol extract of Polygala rosmarinifolia whole plant (100 mg/kg and 200 mg/kg body weight) to alloxan induced diabetic rats for 14 days reduced the elevated level of lipid peroxidation (LPO). The trea...
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF AMLODIPINE BESYLATE
Mouth dissolving tablets is the fast growing and highly accepted drug delivery system, convenience of self administration, compactness and easy manufacturing. Amlodipine besylate is a drug that is used for treating high...
ENHANCING SOLUBILITY AND DISSOLUTION OF CELECOXIB BY SPRAY DRYING TECHNIQUE
Celecoxib, a selective COX-2 inhibitor, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of celecoxib by preparing cry...
EVALUATION OF “YAK001” FOR SAFETY PROFILE: ACUTE ORAL TOXICITY STUDY
This study determines acute toxicity of a coded drug “YAK001” an oral formulation prepared with suspension of test drug using gum acacia in rats. It was assessed for single dose acute toxicity by employing OECD guideline...