SPECTROPHOTHOMETRIC DETERMINATION OF GATIFLOXACIN THROUGH COMPLEXATION WITH SURFACTANT
Journal Title: International Journal of Pharma Sciences and Research - Year 2010, Vol 1, Issue 2
Abstract
A simple, quick and sensitive U.V spectrometric method has been developed for the quantitative estimation of Gatifloxacin in bulk and pharmaceutical formulation. The method was based on the complexation with neutral surfactant, Tween-20 in aqueous phosphate buffer at PH 7.4 which showed an absorption maximum at 295nm and obeyed Beer’s law in the concentration range 2µg/ml to 14µg/ml which was based on the formulation of a U.V sensitive complex known as Europium. The limit of detection and quantification were calculated and relative standard deviation were less than 1.242. The results of analysis for the method has been validated statistically and by recovery studies the results obtained with the proposed method were in agreement with the labeled amounts.
Authors and Affiliations
D. MADHURI , K. B. CHANDRAEKHAR , G. SOMASEKHAR , K. HARINADHABABA , M. RAMKOTIAH , B. DHANDAPANI
Keywords
Related Articles
- EP ID EP144875
- DOI -
- Views 146
- Downloads 0
SIMPLE COLORIMETRIC ASSAY FOR MICROGRAM DETERMINATION OF BROMHEXINE HYDROCHLORIDE WITH MBTH AND 2, 2’ BIPYRIDYL
The present work describes two new spectrophotometric methods for the determination of bromhexine hydrochloride in bulk and formulations. Method A is based on the reduction of Fe3+ into Fe2+ by the drug followed by the c...
Homology Modelling and Insilico Analysis of Hemagglutinin Protein from H1n1 Influenza A Virus
World wide spread of H1NI Influenza A Virus has raised concerns. Modelling of Hemagglutinin protein of Influenza A virus (A/Sakai/1/2009(H1N1)) Hemagglutinin (HA) protein was done using Modeller 9V2. Modelled structure w...
Inhibition efficiency of urine towards stone forming minerals.
Urine specimens were collected from 100 normal individuals and 100 kidney stone patients and analysed spectrophotometrically for common stone promoters like oxalate, calcium, uric acid and phosphate and stone inhibitors...
Aloe vera: Plant of Immortality
The Egyptians called Aloe the “Plant of Immortality” because it can live and even bloom without soil. Aloe has been used medicinally since at least the first century C.E. and continues to be used extensively worldwide....
Hepatoprotective Activity of Leucas lavandulaefolia Against Carbon tetrachloride-Induced Hepatic Damage In Rats
The aerial parts of [i]Leucas lavandulaefolia[/i] Rees, family Labiatae was tested for hepatoprotective activity against CCl4 in rats. The ethyl acetate extract of [i]Leucas lavandulaefolia[/i] has shown significant act...