SPECTROPHOTHOMETRIC DETERMINATION OF GATIFLOXACIN THROUGH COMPLEXATION WITH SURFACTANT
Journal Title: International Journal of Pharma Sciences and Research - Year 2010, Vol 1, Issue 2
Abstract
A simple, quick and sensitive U.V spectrometric method has been developed for the quantitative estimation of Gatifloxacin in bulk and pharmaceutical formulation. The method was based on the complexation with neutral surfactant, Tween-20 in aqueous phosphate buffer at PH 7.4 which showed an absorption maximum at 295nm and obeyed Beer’s law in the concentration range 2µg/ml to 14µg/ml which was based on the formulation of a U.V sensitive complex known as Europium. The limit of detection and quantification were calculated and relative standard deviation were less than 1.242. The results of analysis for the method has been validated statistically and by recovery studies the results obtained with the proposed method were in agreement with the labeled amounts.
Authors and Affiliations
D. MADHURI , K. B. CHANDRAEKHAR , G. SOMASEKHAR , K. HARINADHABABA , M. RAMKOTIAH , B. DHANDAPANI
Keywords
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