Spectrophotometric Determination of Capacetabine via their Metal Chelate
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 3
Abstract
A simple, sensitive and accurate spectrophotometric method was described for the estimation of Capacetabine(CPB) a prodrug used as a chemotherapeutic agent used to treat of cancer either in pure form or in the tablet.The developed method is based on chelate formation between CPB and Fe (III) in aqueous media. The complex showed an absorption maximum at 335nm with apparent molar absorpitivity of 3.78x10 4 L-M-1Cm-1 and sandell’s sensitivity of 0.050 µg/cm2 respectively. The solution of the coloured complex obeyed beer’s law in the concentration range of 2-20µg/ml. The LOD and LOQ were calculated and RSD were calculated. The chelate composition between CPB and Fe(III) ion was in the ratio of 1:1 determined by Job’s continuous method and by Molar ratio method. The developed colourimetric method was applied for the estimation of CPB in tablets in presence ofcommon excipients without interference.The results obtained by the application of this procedure showed good percentage recoveries.
Authors and Affiliations
Madhuri D, VijayaBharathi K, Chiranjeevi
Keywords
Related Articles
- EP ID EP33386
- DOI -
- Views 296
- Downloads 0
Study on dried fruits properties using osmotic method and response surface methodology
Dehydration or osmotic drying is a process in which partial or all food water removes through putting it in a hypertonic solution of sugar or salt. In this study, in order to determine optimized condition of apple slice...
Formulation and evaluation of Diclofenac potassium transdermal patches for enhanced therapeutic efficacy
Today 74% of the drugs are taken orally and are found not to be safe or effective as desired because they produce wide ranging fluctuation in drug concentration in blood stream. Continuous I.V infusion is recognized as...
Solubility enhancement of an antifungal agent by association with dendrimers
Amphotericin B is a polyene antifungal agent which is not freely soluble in water. The clinical use of amphotericin B is limited by nephrotoxicity and poor water solubility, which leads in some cases to permanent renal...
Preclinical evaluation of antispermatogenic activity of Curcuma amada on cell phone radiation induced infertility in rats
To study the ability of the electromagnetic signals emitted by cellular mobile telephony to affect the biological function of living organisms and mobile radiation exposures are changes in the structure and functional...
Spectrophotometric Determination of Capacetabine via their Metal Chelate
A simple, sensitive and accurate spectrophotometric method was described for the estimation of Capacetabine(CPB) a prodrug used as a chemotherapeutic agent used to treat of cancer either in pure form or in the tablet.T...