Spectrum of chronic diarrhoeal diseases - A cross sectional study

Journal Title: Medpulse International Journal of Pediatrics - Year 2019, Vol 9, Issue 3


Protracted diarrhoea is the most severe form of diarrhoea in infancy and has also been defined as intractable diarrhoea. Its etiology is poorly defined. We have retrospectively evaluated the etiology, the outcome, and the risk factors of 38 children, admitted with protracted diarrhoea and need for hospitalization from 5 January 2013 to 10 January 2016. Children with anatomic abnormalities and/or primary immunodeficiency were excluded. There was an inverse relationship between the number of patients and the age of diarrheal onset (mean age, 2.9 ± 3.5 months). Etiology of protracted diarrhoea was an enteric infection in 18 cased (eight Salmonell, there Staphylococcus, five rotavirus, one adenovirus, one Cryptosporidium), multiple alimentary intolerance (eight cases), familial microvillour atrophy (two), autoimmune enteropathy (two), celiac disease, lymphangectasia, eosinophilic enteropathy, intestinal pseudoobstructiopn, and intestinal neurodysplasia (1 case each). Etiology was not detected in three cases. Overall, 12 children died, five are presently being treated, and 21 had full remission. Comparative evaluation of risk factors between children with protracted diarrhoea and a control population of children with diarrhoea but without the need for hospitalization showed that low birth weight, no breast feeding, history of fatal diarrhoea in a relative and early onset of diarrhoea had a significantly higher incidence in the former. Social background was similar in the two populations. We conclude that at specific etiology can be identified in the majority of cases of chronic diarrhoea. The etiologic spectrum of chronic diarrhoea is broad, but an enteric infection is the most common cause of chronic diarrhoea. The severity of this condition is related, at least in part, to establish risk factors.

Authors and Affiliations

V K Tandon, B K Papnai


Related Articles

A study of clinical profile and etiology of status epilepticus in children at tertiary health care centre

Background: Status epilepticus happens when a seizure continues for a long time (more than half an hour), or when a child has several seizures without time to recover between them. Rapid treatment for status epilepticus...

Study of outcome of bubble CPAP in babies with respiratory distress with respect to antenatal risk factors

Background: Respiratory distress is most common and serious complication in relation with various antenatal factors, which together account for over one-half of all neonatal deaths globally. The respiratory support durin...

Comparison of sleep and behavioral problems in post discharge children of pediatric intensive care with non-hospitalized controls

Background: Sleep and behavior disorders in pediatric survivors of critical illness have been a neglected area of research. We aimed to screen the children admitted in the pediatric intensive care unit for a minimum of 7...

Serum glucose levels in preterm neonates during the first 72 hours of life

Background: Postnatal hypoglycemia is common in preterm neonates. The assessment of blood glucose has become an inherentpart of basic neonatal care in many centres. Aim: To provide useful data for the prevention and trea...

A study of prevalence of neonatal cardiac murmur and it's echocardiographic correlation

Background: The neonatal examination takes place at a time of rapid change within the cardiovascular system as part of adaptation to extra uterine life. These changes may produce murmurs which can be mistaken for heart d...

Download PDF file
  • EP ID EP539237
  • DOI 10.26611/1014934
  • Views 102
  • Downloads 0

How To Cite

V K Tandon, B K Papnai (2019). Spectrum of chronic diarrhoeal diseases - A cross sectional study. Medpulse International Journal of Pediatrics, 9(3), 101-105. https://europub.co.uk/articles/-A-539237