Stem Cell Therapies in Systemic Sclerosis: An Updated Review
Journal Title: Journal of Regenerative Medicine & Biology Research - Year 2020, Vol 1, Issue 2
Abstract
Systemic sclerosis systemic is a systemic autoimmune disease that ultimately leads to severe damage and failure of multiple body organs. The disease is associated with significant morbidity and mortality as well as poor response to the available immunosuppressive therapies. Stem cells particularly hematopoietic and mesenchymal stem cells have recently been shown to be not only safe but also efficacious in the treatment of patients with systemic sclerosis. Autologous transplantation of hematopoietic stem cells has become the standard of care for patients with severe systemic sclerosis. Mesenchymal stem cells, alone or in combination with other therapies, have been shown to be effective in the treatment of certain forms and complications of systemic sclerosis such as chronic sclerodermatous graft versus host disease. The review will discuss the various aspects of systemic sclerosis and it will highlight the role of hematopoietic as well as mesenchymal stem cells in the treatment of systemic sclerosis.
Authors and Affiliations
Rehab Y Al-Ansari, Khalid A Al-Anazi
Keywords
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- EP ID EP698847
- DOI http://dx.doi.org/10.46889/JRMBR.2020.1202
- Views 94
- Downloads 0
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