Strategies in Dendritic architecture for drug delivery – An over review
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
Dendrimers represent a novel class of structurally controlled macromolecules derived from a braches upon branches structural motif. These consist of highly branched moieties that radiate from a central core and synthesizes through a stepwise repetitive reaction sequence. In the field of pharmaceutical nanotechnology and medicinal chemistry dendrimers play a vital role based on the structural advantage such as size, shape, surface and interior chemistry flexibility and topology. Dendrimers have emerged as highly gifted drug delivery molecule because of their exceptional structure and properties. Solubility enhancement is an important aspect of dendrimers and this is a synergy with site specific drug delivery. Solubilisations of hydrophobic drug molecule are easily achieved by the dendrimers because they were entrapped in hydrophobic channels. Extracellular matrix of tissue particularly vascular tissue it contains a high concentration of negatively charged glycosaminoglycans which are involved in regulation of cell motility cell proliferation in the regulation of enzyme activity. Extra cellular matrix can be used as a substrate for binding and retention of drug delivered intra vascularly. Recently dendrimers have caused an explosion in biomedical science and created interest in the discovery of the drugs by virtue of their therapeutic value. The dendrimer polymer suggest that they are promising drugs wound healing ,bone mineralization cartilage formation, tissue repairing topical treatment for AIDS to prevent HIV transmission. It also acts as an anti prion, anti Alzheimer, anti coagulants, anti dots, anti inflammatory and anti cancer agents.
Authors and Affiliations
Pandurangan Dinesh Kumar, Palanirajan Vijayaraj Kumar, Govindaraj Saravanan
Keywords
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