STUDY OF A POPULATION OF GLASS CERAMIC WORKERS WITH POSSIBLE CHRONIC KIDNEY DAMAGE DUE TO TOXIC POISONING

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STUDY OF A POPULATION OF GLASS CERAMIC WORKERS WITH POSSIBLE CHRONIC KIDNEY DAMAGE DUE TO TOXIC POISONING

Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 3

Abstract

A sample was studied of the population possibly exposed to lead (Pb) due to their employment in ceramic glass. Of a very heterogeneous population, 219 workers interviewed and 129 workers selected for study participation. Who due to their on-the-job seniority, susceptibility and type of work that they carried out, suspected of having been exposure to Pb. Average Pb in blood was 17.4 ± 14.2 µg/dl, with a minimal value of 0.5 and maximal of 59.6 µg/dl. The 58% of the population analyzed was found with high Pb absorption magnitude with Blood Pb (BPb) >15 µg/dl, including 12% of workers >40 µg/dl. Average gamma-AminoLevulinic Acid Dehydratase (–ALAD) enzyme activity in blood, as a specific indicador of chronic Pb-associated damage, was 379 (nmoles)/ml/h of blood, finding 57.3% of workers with high Pb-related toxicity, reflecting that there are Pb accumulation and redistribution phenomena, given the chronic exposure. Data found in workers of oxidative damage in blood, alterations in neuromuscular behavior and motor coordination, and subclinical and clinical data compatible with exposure to and damage due to Pb. In addition, clinical data of Pb poisoning, proteinuria and persistent albuminuria found in 20% of the workers, indicating possible chronic kidney disease.

Authors and Affiliations

Calderón- Salinas J. Víctor, Maldonado Vega María

Keywords

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EP ID EP550801
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