Study of analgesic and anti-inflammatory activity of different fractions from Kydia calycina Roxb
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 1
Abstract
The present study was carried out to evaluate the analgesic and anti-inflammatory activity of various fractions of toluene, ethyl acetate, butan-2-one and n-butyl alcohol of Kydia calycina Roxb (Malvaceae). The fractions of the plant material were evaluated for the analgesic activity by acetic acid-induced writhing test, Eddy’s Hot plate test in mice and formalin-induced test and anti-inflammatory activity was screened by Carrageenan-induced rat paw edema and cotton pellet induced granuloma formation in rat models. The test fractions were showed analgesic and anti- inflammatory effect in dose dependent manner and ethyl-acetate fraction was found to be most potent among the test fractions. At 150mg/Kg b.w.p.o dose Ethyl-acetate fraction significantly inhibited 69.02% writhing response and 64.28%, 78.21% Formalin induced analgesic in mice. The fraction with same dose showed significant 70.87% inhibition of Carrageenan induced rat paw edema and 42.72, 39.16% anti-proliferative effect of cotton pellet in rats and also different fractions of Kydia calycina Roxb showed prompt analgesic and anti-inflammatory activity due to dual inhibition properties on COX-2 and 5-LOX.
Authors and Affiliations
Babu Rao Bhukya
Keywords
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