Study of changes in clinical symptoms and some biologic parameters in asthma patients allergic to D.pteronyssinus treated by sublingual and subcutaneous immunotherapy
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2018, Vol 9, Issue 28
Abstract
Introduction. Although subcutaneous immunotherapy (SCIT) is traditional method for allergic asthma treatment, it has disadvantages that are the reasons why patients refuse the treatment. However, Sublingual immunotherapy (SLIT) seems to be safe and easy to use. Objective. to evaluate the changes of clinics and immunologic parameters in allergic asthma patients to Dermatophagoides pteronyssinus (Dp) treated by SLIT and SCIT before and after 6 months of treatment. Method. All patients diagnosis specific allergic asthma to Dp were divided into 2 groups: group 1 including 30 patients treated with SLIT and group 2: 30 patients treated with SCIT. This is a blind placebo study method at Haiphong Medical University Hospital. Results. Clinical symptoms decreased significantly (p<0.01) in both groups. Total IgG increased in both groups. Total IgE, destroying mastocyte decreased (p<0.01) in both groups. However, No difference can be found in clinical and immunological changes in allergic asthma patients treated by SLIT compared with SCIT (p>0.05). Conclusions. SLIT and SCIT were clinically effective and safe in allergic asthma to Dp treatment. But SLIT seems to be safe and easy to use more than SCIT.
Authors and Affiliations
Thuc PHAM VAN
Keywords
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- EP ID EP570342
- DOI 10.12699/jfvpulm.9.28.2018.53
- Views 77
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