Chemotherapy use at the end of life in metastatic non small cell lung cancer: practical analysis
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2017, Vol 8, Issue 25
Abstract
Background. End of life cancer care has become more aggressive. Scarce studies have explored the factors associated with the aggressiveness of cancer care near the end of life (EOL) in non-small cell lung cancer (NSCLC) patients. The aim of the study was to evaluate chemotherapy use at the EOL in patients with primary metastatic NSCLC. Methods. We conducted a retrospective study which included expired patients diagnosed with primary metastatic NSCLC and who died within 3 months of diagnosis between January 2007 and December 2013 in our thoracic oncology unit. Results. A total of 183 patients were included. Median age of the patients was 60 years old. The proportion of patients who received chemotherapy in the last three months of life was 31.9%, in the last month 10.4% and in the last two weeks 6.5%. Two point five percent of the patients had a new chemotherapy regimen in the last month of life (LMOL). Patients who didn’t undergo chemotherapy in the LMOL had a median overall survival (OS) of 10.36 months, while median OS for patients who received chemotherapy in the LMOL was 6.86 months (p=0.128). Median survival for patients who didn’t undergo chemotherapy in the last 14 days before death was 9.96 months while median survival for patients who underwent chemotherapy in the last 14 days was 6.83 months (p=0.763). Conclusion. Our results showed that no survival benefit was found in continuing chemotherapy in the LMOL. Further study is needed to better identify predictors of aggressive care near the EOL.
Authors and Affiliations
Saoussen BACHA
Keywords
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- EP ID EP367848
- DOI 10.12699/jfvpulm.8.25.2017.8
- Views 79
- Downloads 0
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