Study of clinicopathological characteristics of infiltrating duct carcinoma of breast with micropapillary carcinoma component
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 7, Issue 2
Abstract
Background: Infiltrating duct carcinoma (IDC) - Not otherwise specified or No specific type is the most frequent histological type of breast carcinoma. Invasive micropapillary carcinoma (MPC) is a distinct istological constituting less than 3% of invasive breast cancers. This study seeks to determine the incidence of IDC of breast which show MPC component and also to determine if tumors with an associated micropapillary carcinoma component are prognostically different from tumors without this component. Aim of the study: 1.To determine the proportion of cases of IDC of breast which have a micropapillary carcinoma component, to compare various pathological features in IDC with and without micropapillary component and to study the relationship of tumors with micropapillary carcinoma component with clinical parameters like-age, gender, location of primary tumor, tumor size and stage. Materials and Methods: This study was carried out in the department of pathology at Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra over a two and half year period from May 2006 to September 2008. Observations and Results: Forty three (11.9%) out of 361 consecutive cases of infiltrating duct carcinoma (IDC) showed micropapillary carcinoma component (MPC). Forty two cases showed micropapillary carcinoma component mixed with IDC and only one case showed pure micropapillary carcinoma. There was no association between proportion of MPC component and histologic grade, lymphocytic infiltration, lymphovascular invasion, lymph node metastases or stage. Almost 56% of the cases presented in the third and fourth decade of life. Tumor size was larger than 5cm in 60.4% cases. Micropapillary tumors showed elastosis, extensive DCIS component and associated necrosis in a significantly higher proportion of cases compared to nonmicropapillary tumors. Lymphovascular invasion and nodal metastases, higher stage (stage III and IV) were found in a significantly higher number of cases with MPC component. Conclusion: Tumors with MPC component are highly lymphotropic and behave more aggressively with frequent lymphovascular invasion, extensive nodal metastases and high stage. It is a significant independent predictor of high stage tumors. It is an undermentioned entity in routine surgical pathology reporting. We recommend that the presence of micropapillary carcinoma component must be documented in the Surgical Pathology report, in view of its aggressive behaviour.
Authors and Affiliations
Chaukade S V, Sharma S M, Gangane N, Anshu 4
Keywords
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Study of clinicopathological characteristics of infiltrating duct carcinoma of breast with micropapillary carcinoma component
Background: Infiltrating duct carcinoma (IDC) - Not otherwise specified or No specific type is the most frequent histological type of breast carcinoma. Invasive micropapillary carcinoma (MPC) is a distinct istological c...