Study of Level of various Infertility hormones like FSH, LH, Testosterone, Thyroid hormone and Prolactin in obese hyperglycemic and non-obese normoglycemic women of polycystic ovarian syndrome (PCOD) in southern Rajasthan, India
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 9
Abstract
Abstract: The polycystic ovary syndrome (PCOS) is a mostly hyper androgenic disorder and is possibly the most common endocrinopathy of premenopausal women. The primary defect in polycystic ovary syndrome (PCOS) appears to be an exaggerated androgen synthesis (testosterone) (secretion by the ovaries and the adrenal glands) and hyperglycemia or insulin resistance.The objective of the study is to study the level of various Infertility hormones like FSH, LH, Progesterone, Estradiol, Testosterone, Insulin, HOMA-IR, Thyroid hormone (T3,T4,TSH)& Prolactin and in obese hyperglycemic and non-obese normoglycemic women of Polycystic ovarian syndrome(PCOD).This study includes total 500 female participants of age Group between 18-40 year of age. They were divided in to two group. Group 1(n=300) includes women having PCOD and Group 2(n=200) is control Group. Fasting Blood samples were obtained from all participants to measure Blood sugar, Lipid Profile, Testosterone, Progesterone, Estradiol FSH, LH, Insulin, HOMA-IR, Thyroid hormone(T3,T4,TSH) and Prolactin. History of PCOD women also had taken with Age, Menstrual cycle, hirsutism, acne, BMI, Waiste Hip ratio & Veg or Occasional Non-veg food diets.The Mean level of FastingBlood sugar, S. cholesterol, S.Triglyceride, S.Insulin, S. Testosterone, S. Estradiol ,S.FSH ,and S.LH is found to be higher in both obese hyperglycemic & non-obese normoglycemic PCOD group (Except: S. Progesterone) as compared to control group and difference among them found to be statically significant. In PCOD women were also finds symptoms of oligomenorrhoea or anovulatory menstrual cycle, histustim with different F-G score, obesity in different ratio.From our study I would like to conclude that Obesity is a common finding in PCOS and aggravates many of its reproductive and metabolic features. The relationship between PCOS and obesity is complex, not well understood, and most likely involves interaction of genetic and environmental factors. Insulin resistance and weight gain are two contributing factors to PCOS. Insulin resistance typically causes the body to produce more insulin than normal (hyperinsulinemia). Higher levels of insulin can then cause ovaries to produce too much testosterone which can impair normal ovulation from occurring. Hyperandrogenism caused other secondary characteristics like Virilization, hirsutism (hairs on body), acne, obesity etc. These symptoms differ according to age of PCOD women, early age hyperandrogenism which further leads to metabolic syndrome with insulin resistance in later age. Keywords: PCOD, Testosterone, Insuline, FSH, LH ,Prolactin, Progesterone, Estradiol, Thyroid hormone
Authors and Affiliations
Renu Sharma, MrsAkansha menaria, A K Verma
Keywords
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