Study Of MIC & MBEC Of Planktonic & Sessile Form Of Biofilm Strains Of Urinary Catheter(> 1m In-Situ)With Nitrofurantoin In A Tertiary Care Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Biofilms are complex communities of single or multiple spp of microorganisms that develop on abiotic & biotic surfaces.Since biofilms contaminate catheters,ventilators & medical implants,they act as a source of disease in humans.They also represent a barrier of eradication as the physiological state of bacterial cells within biofilm confers high level resistance to antibacterial substance. In this study; >1 month urinary catheters in-situ have been selected as clinical samples due to their prompt availability with pre-formed biofilms on most of them. During evolution of biofilm increasingly resistant sub-populations appear with time. Drug sensitivity of planktonic form of a potential biofilm-producing organism is determined by minimum inhibitory concentration(MIC)value, while minimum biofilm elimination concentration (MBEC) value denotes the drug concentration required to eliminate highest resistant sub-population within the biofilm.So MEBC is variable depending upon maturation of biolfilm with colonisation of highly resistant sub-populations.In this study an attempt has been made to compare the MIC value of planktonic form with MBEC value of sessile form of same organism in preformed biofilm.Nitrofurantoin has been choosen for this study as the drug is widely used as urinary antiseptic.
Authors and Affiliations
Dr. Purnima Mondal, Dr. Sudipta Kumar Maity, Prof. (Dr. ) Prasanta Kumar Maity
Keywords
Related Articles
- EP ID EP380770
- DOI 10.9790/0853-1708024348.
- Views 63
- Downloads 0
Evaluation and Comparision of Antimicrobial Effects of Chlorhexidine (CHX) and Chitosan (CHT) Mouthwash in Chronic Periodontitis (CGP) Patients – A Clinicomicrobiological Study
Aim: The objective of study is to investigate the in vivo antibacterial effects of 0.12% CHX and 2% CHT in adjunct to Scaling and Root Planing (SRP) on plaque microbiota in patients with CGP. Methods: The study was condu...
A Study of Relationship between Great Saphenous Vein and Superficial External Pudendal Artery and Duplication of Great Saphenous Vein in South Indian Population [Original Article]
The varicose veins are a relatively common condition of the lower limb for which surgery is the main modality of treatment. An anomaly of the Sapheno femoral junction should always be taken into consideration in order to...
Crown-Implant Ratio versus Crown-Root Ratio – A Review
The terms crown root ratio and crown implant ratio have always been a controversial topic for determining the diagnosis, treatment planning and prognosis of a prosthesis due to scarcity of evidence based research on the...
Effect of Thermocycling and Polyethylene Fibre Addition on Impact and Transversal Strength of Heat Cured Acrylic Resin Denture Base Material
Background: Heat cured acrylic resin is the most widely used material in the manufacture ofdenture base, but has mechanical properties weakness (transversal strength and impact strength). Alternative to increase the mech...
A Study of Periodontal Disease and Diabetes Mellitus in Abuja Nigeria.
Background:Periodontal disease is essentially a combination of gingivitis, which is aninflammatory condition of the gingiva and periodontitis, which refers to the destruction of the periodontal ligament, alveolar bone an...