Study Of MIC & MBEC Of Planktonic & Sessile Form Of Biofilm Strains Of Urinary Catheter(> 1m In-Situ)With Nitrofurantoin In A Tertiary Care Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Biofilms are complex communities of single or multiple spp of microorganisms that develop on abiotic & biotic surfaces.Since biofilms contaminate catheters,ventilators & medical implants,they act as a source of disease in humans.They also represent a barrier of eradication as the physiological state of bacterial cells within biofilm confers high level resistance to antibacterial substance. In this study; >1 month urinary catheters in-situ have been selected as clinical samples due to their prompt availability with pre-formed biofilms on most of them. During evolution of biofilm increasingly resistant sub-populations appear with time. Drug sensitivity of planktonic form of a potential biofilm-producing organism is determined by minimum inhibitory concentration(MIC)value, while minimum biofilm elimination concentration (MBEC) value denotes the drug concentration required to eliminate highest resistant sub-population within the biofilm.So MEBC is variable depending upon maturation of biolfilm with colonisation of highly resistant sub-populations.In this study an attempt has been made to compare the MIC value of planktonic form with MBEC value of sessile form of same organism in preformed biofilm.Nitrofurantoin has been choosen for this study as the drug is widely used as urinary antiseptic.
Authors and Affiliations
Dr. Purnima Mondal, Dr. Sudipta Kumar Maity, Prof. (Dr. ) Prasanta Kumar Maity
Keywords
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- EP ID EP380770
- DOI 10.9790/0853-1708024348.
- Views 70
- Downloads 0
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