Study of P53 Expression in Dysplasia and Squamous Cell Carcinoma of Upper Aerodigestive Tract: An Ominous Sign
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Background: Oral squamous cell carcinoma (SCC) is one of the most common malignancy and is a major cause for morbidity and mortality in developing nations. The objective of the study was to assess p53 expression in a range of upper aerodigestive tract lesions to relate the results to the clinical outcome in patients with dysplastic lesions and SCC. Materials and Methods: The expression of p53 was investigated by immunohistochemistry method in 50 histopathologically diagnosed patients which comprised of 15 dysplasia cases and 35 SCC cases of upper aerodigestive tract region. The expression of p53 was scored based on percentage of positive tumor cells and the staining intensity. Results: The expression of p53 was detected in 60% of dysplastic lesions and 71% of SCCs. There was significant increase in staining intensity and percentage of tumor cells expressing p53 from dysplasia to different grades of SCC. Conclusion: Present study concluded that combined histological analysis along with p53 immunoexpression can improve the evaluation of premalignant and malignant lesions for treatment.
Authors and Affiliations
Priyanka Gupta, Kishore Shaw
Keywords
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- EP ID EP415540
- DOI 10.9790/0853-1711067881.
- Views 58
- Downloads 0
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