Study of Predictive and Prognostic Markers in Breast Cancer with Special Reference to Hormonal Receptors
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Aim: To study pattern of expression of Hormone receptors- ER, PR and HER2 in breast carcinoma and to correlate ER, PR status and HER2/neu expression with traditional prognostic factors. Background: Breast cancer is one of the most common cancers in females. As breast carcinoma is a biologically heterogeneous disease, it is important to assess prognosis for each patient before a therapeutic plan is agreed upon .The use of established biomarkers such as estrogen, progesterone receptors and Her2 over expression play significant role in management of patients. Material Methods: Total 54 histologically proved cases of breast carcinoma in Department of Pathology of the Institute were included in the study. All histopathological and hormonal receptor studies were done on specimens obtained in histopathology section. Detailed report of breast carcinoma that included evaluation of prognostic and predictive markers was given in each case. The correlation between Hormonal and Clinicopathological markers was analysed using Chi square test and Fisher exact test. Results: ER, PR positivity and Over-expression HER2 was seen in 48.15%, 55.56% and 38.89% respectively. Correlation between ER, PR and tumour grade was found to be statistically significant (p<0.05). No significant correlation was found between ER-PR status and Her2 positivity with other traditional prognostic factors. Conclusion: Traditional gross and microscopic features of carcinoma of breast are important as independent prognostic markers. In addition ER, PR and HER2 should be assessed in every case of breast carcinoma as prognostic and predictive markers.
Authors and Affiliations
Neha R Malviya, Sandhya V Poflee
Keywords
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- EP ID EP395520
- DOI 10.9790/0853-1709123136.
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