STUDY OF PREVALENCE AND PATTERN OF BONE MARROW INVOLVEMENT IN LYMPHOMAS - A TERTIARY CARE HOSPITAL STUDY IN KASHMIR.
Journal Title: INTERNATIONAL JOURNAL OF RESEARCH IN PATHOLOGY AND MICROBIOLOGY - Year 2017, Vol 1, Issue 1
Abstract
BACKGROUND: BM infiltration by lymphoma places the patient in Stage IV disease and these patients manifest poor prognosis and response to treatment. In patients with bone marrow involvement by lymphomas, the marrow smears and trephine sections are collectively interpreted for cytology,pattern of bone marrow infiltration,and sometimes Immunophenotyping. Materials and methods: A 5 year (Jan 2013 to Dec'17) study was conducted in the Deptt. of Pathology and Clinical Hematology, SKIMS.All the cases reported as NHL & HL were reviewed and analyzed.The data included bone marrow aspiration and bone marrow biopsy samples and relevant blocks and slides.In this study we tried to study prevalence and pattern of bone marrow involvement in NHL & HL. Results :NHL to HL ratio was (7:1). DLBCL was the most common (54.3%) subtype followed by FL(7.8%), SLL (6.8%).NHL pts. were in the age group of 41-60 yrs whereas HL were of 21-40 yrs. Male to female ratio is equal to 2:1.Infiltration was seen in 22.6% cases in BMB and in 18.3% cases in BMA.Infiltration was commonest in LPL (75% cases), f/b SLL 63%), FL (50%), ALCL (42.9%), MZL (37%), DLBCL(20.8%), BL (25%), MCL (16%) & HL (7%).Diffuse pattern of infiltration was most common followed by interstitial,mixed,paratrabecular and nodular .The reliability of BMB was significantly higher than that of BMA. Conclusion:We conclude that Bone marrow examination is an important investigation in cases of Lymphoma which has a prognostic and at times diagnostic relevance. The highest frequency of marrow disease was encountered in elderly patients with indolent lymphomas. The BMB had a higher diagnostic validity whereas; BMA served a good test in screening lymphomas positive for marrow disease. However, a negative BMA does not exclude marrow involvement.Pattern of infiltration showed significant variation in bone marrow involvement Immunohistochemistry increased the diagnostic accuracy.HL had a low rate of BM involvement.
Authors and Affiliations
Dr Salma Gull, Dr Nuzhat Samoon, Dr Jasif Nisar, Dr Mohd Iqbal Lone
Keywords
Related Articles
- EP ID EP651963
- DOI -
- Views 92
- Downloads 0
MORPHOLOGICAL SPECTRUM OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS- A SEVEN YEAR STUDY FROM CENTRAL INDIA
INTRODUCTION: Tumors of the nervous system are important cause of cancer-related deaths in children. There are several reports regarding the epidemiology of CNS tumors in children in the Western literature but too few re...
CLINICOPATHOLOGICAL SURVEY OF CARCINOMA UTERINE CERVIX IN PATIENTS ATTENDING TERTIARY CARE HOSPITAL OF CENTRAL UTTAR PRADESH
Carcinoma cervix is the third most common cancer in women worldwide and the commonest cause of mortality in developing countries. The present survey was conducted with the aim to study the different histopathological sub...
HEPATIC ADENOMATOSIS – A CLINICALLY CHALLENGING RARE LIVER DISEASE
43-year-old lady presented with incidentally discovered liver lesions while she was being managed for her complaints of menorrhagia. CT and MRI showed hepatomegaly with multiple lesions in both lobes of the liver with va...
A STUDY ON THE RATE OF OCCURRENCE OF H. PYLORI IN DYSPEPTIC PATIENTS IN A TERTIARY CARE HOSPITAL
INTRODUCTION: Helicobacter pylori (H. pylori) chronically infect more than half of all people worldwide. We explore the rate of occurrence of H pylori in dyspeptic patients and its causal association with peptic ulcer di...
TO STUDY THE OUTCOSME FOLLOWING COMBINED MANAGEMENT OF FRACTURE DISTAL END OF FEMUR WITH IPSILATERAL PATELLAR FRACTURE: A PROSPECTIVE AND DESCRIPTIVE STUDY.
AIM: To study the outcome following combined management of fracture distal end of femur with ipsilateral patellar fracture. METHODS: A hospital based Prospective, Interventional and Descriptive study was done at Departme...