Study of Serum Lipid Profile in Beta-Thalassemia Major Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 7
Abstract
Objectives 1. To assess the Serum Lipid Profile of patients with Beta-Thalassemia Major. 2. Comparison of the Serum lipid profile of Beta-thalassemia major patients with healthy children. Study Design: This was a cross sectional case control study in which 100 diagnosed cases of Beta thalassemia major were enrolled. 100 healthy children of same age group consisted of control group. The blood samples of study and control groups were examined for lipid profile test and values were evaluated. The tests were done using Olympus AU400 Auto analyser and values were evaluated. Statistical analysis was done by using IBM SPSS version 20. Results: Mean age of cases was 9.04 ± 4.11 years and of controls was 8.92 ± 4.0 years. The mean values of serum HDL-C, LDL-C, total cholesterol, TG and VLDL in cases were 26.5±8.9, 62.1±21.9, 111.8 ±26.7, 112.06±53.40, 25.58±21.15 mg/dl respectively. Moreover, the mean values of serum HDL-C, LDL-C, total cholesterol, TG and VLDL in controls were 47.6±4.3, 76.8 ±15.4, 76.8 ±15.4, 74.64±16.23, 22.63±6.6715 mg/dl respectively. Total-cholesterol to HDL-C ratio was4.57±1.55 and 2.66±0.39 in cases and controls respectively. Total cholesterol, HDL-C, LDL-C were significantly lower (p<0.05); triglycerides and total cholesterol & HDL ratio were significantly higher (p<0.05) compared with controls. Conclusion: Beta thalassemia major patients have hypertriglyceridemia and hypocholesterolemia. This study concludes that children suffering from beta thalassemia major may possess increased risk of thrombotic and atherogenic complications. Early detection of these patients with deranged lipid profile is required to avoid these complications. It is also important to do routine periodical screening
Authors and Affiliations
Dr Suraj Doshi
Keywords
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