Study of serum Malondialdehyde, nitric oxide and vitamin E in rheumatoid arthritis patients before and after the supplementation of vitamin E
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 1
Abstract
Background: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder that may affect many tissues and organs – skin, blood vessels, heart, lungs and muscles but principally attacks the joints, producing a non suppurative proliferative and inflammatory synovitis that often progresses to arthritis and ankylosis of the joint. The exact reason behind bone erosion and joint deformities is not fully understood. Formation of reactive oxygen species and lipid peroxides as a result of disease activity may play an important role in RA. There is a close association between bone loss and oxidative threat in patients presenting with RA. Objectives: To evaluate the preventive role of antioxidant therapy in RA by measuring serum Malondialdehyde (MDA), Nitric oxide (NO), and Vitamin E before and after co-administration of vitamin E 400 mg/day for 12 weeks. Methods: In this study50 RA patients who were fulfilling the ARA-1987 revised criteria were included and they are divided into two groups. Results: In RA patients, after vitamin E therapy, serum MDA, NO levels were statistically highly significantly (p<0.001) reduced and Vitamin E statistically highly significantly (p<0.001) increased as compared to RA patients who had not received vitamin E therapy Conclusion: There was decrease in oxidative stress in RA patients with Vitamin E therapy. The results suggest proper antioxidant nutrient intake may reduce free radical generation and improve antioxidant status and thus reducing the morbidity in RA patients.
Authors and Affiliations
Swapna V S, Triveni Jambale, Dinesh Javerappa, Srinivasa Deshpande
Keywords
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