STUDY OF SERUM THYROGLOBULIN IN DIFFERENTIATED THYROID CARCINOMA
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 24
Abstract
The pattern of serum Thyroglobulin levels in thyroidectomised patients with differentiated thyroid carcinoma (DTC) was studied in retrospect. The serum thyroglobulin (Tg) levels during follow up after initial therapy, in remnant disease, association with metastasis and recurrences were evaluated. Serum thyroglobulin mean values of 4.78±0.4 ng/ml were observed in 37 subjects with successful initial therapy and no residual disease. In the group of subjects with residual disease serum thyroglobulin levels were 35.80±8.1 ng/ml. In contrast, patients with documented metastasis had serum thyroglobulin ranging from 20-1000 ng/dl with a mean of 470±369 ng/ml (n=23). Statistically significantly high values were noted in the group of subjects with metastasis at admission (n=6) and those with recurrence and metastasis (n=8) after a disease free period of 6 yrs (2-17 years) their mean values ranged from 403.85±311 ng/ml to 608±395 ng/ml respectively. In DTC with recurrence in the remnant (n=9) with a mean duration of 3.5 years following successful therapy the serum thyroglobulin levels were 159±102 ng/ml. In all the above subjects the serum thyroglobulin values profiled were over the accepted normal range of 0-10 ng/ml. This retrospective study reiterates the premise that thyroglobulin measurements provide a sensitive and pragmatic parameter in treatment and follow up of patients with differentiated thyroid carcinoma.
Authors and Affiliations
Madhuri Sepuri, Prasadula Ashok, Shashiprabha K
STUDY OF HYPOMAGNESAEMIA IN CRITICALLY-ILL PATIENTS IN MEDICAL INTENSIVE CARE UNIT AT TERTIARY CARE HOSPITAL
BACKGROUND Magnesium is the second most abundant intracellular cation and the fourth most common cation in the body. The effect of magnesium on important biological processes such as glycolysis, oxidative phosphorylation...
EPIDEMIOLOGY AND CLINICAL PROFILE OF HEPATIC ENCEPHALOPATHY IN TERTIARY CARE HOSPITAL, GGH, KAKINADA
BACKGROUND Hepatic Encephalopathy (HE) is defined as a spectrum of neuropsychiatric abnormalities in patient with liver dysfunction, after exclusion of other known brain diseases. It is a potentially reversible condition...
A PROSPECTIVE STUDY OF NON-DESCENT VAGINAL HYSTERECTOMY
BACKGROUND The aim of the study is to assess the outcome in terms of safety, complication and feasibility of non-descent vaginal hysterectomy for benign gynaecological disease. MATERIALS AND METHODS A prospective study t...
DIETARY RISK FACTORS OF METABOLIC SYNDROME IN DIBRUGARH DISTRICT OF ASSAM
BACKGROUND As India is considered as the diabetic capital of the world, a huge burden of undiagnosed Metabolic Syndrome (MetS) is a possibility. Early intervention can be planned if MetS can be detected early along with...
CONGENITAL CYSTIC ADENOMATOID MALFORMATION OF LUNG: A CASE REPORT
Congenital cystic adenomatoid malformation (CCAM) is a rare developmental abnormality of the lung previously termed as 'benign hamartoma' or 'dysplastic lung tumor'. It is characterized by abnormal proliferation of tissu...