Study of Serum Uric Acid Levels and BMI in Patients with Nafld, a Observational Study at a Tertiary Care Centre of Central India.
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 5
Abstract
Introduction: Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of conditions from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis, NAFLD has been considered as the hepatic manifestation of metabolic syndrome.The association between serum uric acid concentration and metabolic syndrome has been demonstrated in previous studies, which leads us to speculate that there might be a relationship between uric acid concentrations and NAFLD. The aim of the present study was to investigate the association of serum uric acid level and body mass index (BMI) with NAFLD. Material and Methods: A total of 120 subjects including 60 known cases of NAFLD attending outdoor clinics of MY Hospital and 60 age and sex matched healthy controls. Fasting venous blood sample was analysed for uric acid by uricase/peroxidase method. Statistical analysis was performed using SPSS software. Results: In our study there were 26 women and 34 men as cases and 21females & 39 males in control group. Mean BMI of NAFLD cases were 32 ± 3.48 and that of control group was 27 ± 2.56. Difference between the two groups were statistically significant. Mean serum uric acid in case group were 6.78mg/dl and that of control group it was 4.28. The difference in uric acid levels between cases and control were statistically significant. Conclusion: Study concluded that increased serum uric acid concentrations are a risk factor in NAFLD. The possible pathogenetic role of uric acid in NAFLD and the metabolic syndrome deserves to be further studied.
Authors and Affiliations
Akash Bansal, Rajeev Lohokare, Purnima Dey Sarkar, Pravesh Hargaonkar
Keywords
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