Study of the rheological characteristics of the praziquantel semisolid dosage form for external use
Journal Title: Фармацевтичний журнал - Year 2016, Vol 1, Issue 1
Abstract
Structural-mechanical characteristics exert a significant influence on the processes of the medications releasing, absorption in ointments and their consumer properties: spreadability, adhesion, extrudability from the tubes. In this connection evaluation of the rheologic properties is an important and inevitable fragment of the investigations in the realm of making of the semisolid dosage forms for the dermatologic practice. Efficient composition of the semisolid dosage form – ointment (cream) with praziquantel for the topical etiotropic pharmacotherapy of the acne similar dermatosis was developed on the department of technology of medication in Zaporozhye State Medical University as a result of the complex physico-chemical, pharmacotechnological and microbiological investigations. The aim of this work is study of consistent properties of the developed ointment composition. Study of structural-mechanical characteristics of the composition was carried out by the rotary viscosimeter Reotest-2 with cylindrical arrangement. As a result of the experiment it was established that consistent properties of the cream for external use with praziquantel 3% are practically thoroughly situated within rheologic optimum of consistence limits. Mechanical stability (1,19) describes composition as an exceptionally thixotropic system which provides with restorability after applying tension and allows to predict stability of consistent properties during a long-term storage. Calculated factors of dynamical flowing of the praziquantel topical dosage form on the emulsion base (Кd1 = 41,82%; Kd2 = 67,22%) quantitatively confirm satisfactory spreading degree of the system during application on the mucous membranes or in manufacturing process. Insignificant divergence of rheologic characteristics of the cream with praziquantel 3% for external use and its base indicates a deficiency of interactions between active substance and excipients.
Authors and Affiliations
D. M. Romanina, V. V. Gladishev, B. S. Burlaka
Keywords
Related Articles
- EP ID EP561419
- DOI -
- Views 85
- Downloads 0
Analysis of assortment and volumes of consumption of antihistamin preparations in Ukraine
Over the past 30 years, the prevalence of allergic diseases has doubled every 10 years. According to WHO, currently about 5% of the world's adult population and 15% of children suffer from allergic diseases. The purpose...
The substantiation of plant raw materials ratio and determination of raw materials technological parameters in the development of complex tincture for the telogen effluvium treatment
Telogen effluvium is the most common form of diffuse alopecia in women due to concomitant somatic pathology and adverse exogenous factors. Pharmacotherapy of the disease requires the use of active substances that should...
Investigation of lipophilic substances of the leaves and flowers of spindle tree (Euonymus Europaea L.)
Spindle Tree (Euonymus europaea L.) has long been used in folk medicine for the treatment of dermatomycoces and as an antiparasitic and anthelmintic agent. However, with what substances it is associate this activity, it...
Analysis of terminology and definition of components of the process of rational use of drugs in ukraine
According to WHO recommendations, the rational use of drugs includes a block of problem issues, and it is an important area that requires detailed analysis and government regulation through the development of the Nationa...
Studies of heparine solutions preserved in glass and plastic ampoules by the metod of laser desorption mass spectrometry
In this study the practical problem of permissibility of heparin preservation in ampoules made of various materials was investigated by methods of matrix-assisted and matrix-free laser desorption/ionization combined with...