Study of Thyroid Disorders in Pregnancy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Objective: To evaluate thyroid profile in pregnancy with special reference to anti-TPO antibodies and maternal and foetal outcomes in those with deranged thyroid profile. Materials and Methods: It was a prospective study done at Rajendra Hospital and GMC, Patiala. 500 pregnant women with singleton pregnancy irrespective of age, gestational age, parity and socioeconomic status were included. Those with multiple pregnancy and known case of any thyroid disorder were excluded. Written informed consent obtained. A detailed history and examination was done .Along with routine investigations estimation of T3, T4 and TSH was done. In those with deranged thyroid function tests, anti TPO antibody levels was estimated. Patients with deranged thyroid profile were followed up for pregnancy outcomes and maternal and foetal complications during subsequent visits to the hospital or through telephonic registry. Results: From this study it was concluded that prevalence of thyroid disorders in pregnant women was considerably high (11.8%) with subclinical hypothyroidism being the most common (7.6%), followed by overt hypothyroidism (2.6%), subclinical hyperthyroidism (1.2%) and overt hyperthyroidism (0.4%). In cases with subclinical hypothyroidism, pre-eclampsia was the most common maternal complication (13.16%) followed by preterm delivery (7.89%). Statistically significant association with was found in IUGR (p=0.011) and LBW (p=0.011). In overt hypothyroidism, most common maternal complication was preterm delivery (15.38%) while statistically significant association was found with low birth weight. Overall, the association of anti TPO antibody with respect to maternal and foetal complications was found to be statistically significant (p=0.034). Conclusion: The presence thyroid disorders and anti TPO antibody confers a statistically significant risk with respect to increased chances of abnormal pregnancy outcomes as well as maternal and foetal complications during pregnancy. Therefore, it is essential to screen all pregnant women for thyroid dysfunctions with special reference to autoimmune evaluation to reduce maternal and foetal morbidity as well as mortality
Authors and Affiliations
Preetkanwal Sibia, Ankur Chaudhary, Raminderpal Sibia, Deep Inder Singh, Mallika Jain
Keywords
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- EP ID EP556343
- DOI 10.9790/0853-1803103948.
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