Study of Utility of p63 Immunohistochemical Stain to Differentiate Urothelial Carcinomas of Urinary Bladder from Adenocarcinomas of Prostate
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 3
Abstract
Introduction: Cancer of the bladder and of prostate are commonmalignancies all over the world. In some cases it is difficult to point to the exact primary due to the anatomical location and morphology of the tumors from these two sites. Various immunohistochemical markers can be used to identify the primary site and p63 is one such marker. Aim of the study: To study the expression of p63 in urothelial carcinoma and prostatic adenocarcinoma so as to differentiate between the two carcinomas. Materials and Methods: In this study, formalin fixed paraffin blocks from 60 cases of urothelial carcinomas of urinary bladder and 20 cases of prostatic adenocarcinomas were examined on light microscopy and tissue sections from all 80 cases were studied for immunohistochemical staining with p63 marker. Observations and Results: The mean age of patients of urothelial carcinoma and of prostate carcinoma was 54.1 and 64.5 years respectively. There were 28 cases (46.6%) of low grade and 32 cases (53.3%) of high grade urothelial carcinomas. The Gleason score for prostatic carcinoma was 56 for 8 patients, 78 for 9 patients and 910 for 3 patients.In 60 urothelial carcinomas 90% of cases showed p63 positivity. All the 20 cases of prostatic adenocarcinomas were negative for p63. Conclusion: p63 is a reliable marker of urothelial differentiation and it can be used in morphologically difficult cases when the differential diagnosis is between poorly differentiated adenocarcinoma of prostate and high grade urothelial carcinoma of urinary bladder.
Authors and Affiliations
Bhavani Adepu
Keywords
Related Articles
- EP ID EP466277
- DOI 10.21088/ijprp.2278.148X.6317.5
- Views 106
- Downloads 0
Histopathological Study of Spectrum of Bone Lesions: An Experience at Tertiary Care Hospital
Background: The pathological bone lesions are wide array from inflammatory to neoplastic conditions. The X-ray helps in exact location of lesion, but most often times it is very difficult to diagnose and differentiate. T...
Correlation of Transfusion Transmitted Infection, Liver Function Test and Serum Ferritin with Multiple Blood Transfused Thalassemic Patients at Tertiary Health Care Centre
Background: Thalassemia is one of the major hemoglobinopathies among the population all around the world. Beta thalassemia major results in severe anemia which needs regular repeated blood transfusion, which leads to iro...
Prevalence of HIV among Blood Donors at RIMS, Teaching Hospital Blood Bank, Raichur: A Retrospective Study
Aim: To determine prevalence & age and gender distribution of HIV among blood donors and to study the trend of incidence of HIV positive Cases among them. Materials and Methods: This is a retrospective study conducted fr...
Expression of p63 in Benign, In-Situ and Invasive Ductal Carcinoma of Breast
Background: p63 is a member of p53 family of transcription factors which have important function in tumorogenesis and oncogenesis. It is involved in cellular differentiation and exposed in nuclei of myoepithelial cells o...
A Triple Correlation Study - Fine Needle Aspiration Cytology and Imprint Cytology of Lymph node with Histopathological Examination
Introduction:Lymphadenopathy is a term meaning disease of the lymph nodes . It is, however, almost synonymously used with swollen or enlarged lymph nodes due to infection, auto-immune disease or malignancy. FNAC and impr...