STUDY ON NONALCOHOLIC STEATOHEPATITIS (NASH) IN PATIENTS OF OBESE, TYPE 2 DIABETES MELLITUS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 8
Abstract
BACKGROUND Nonalcoholic steatohepatitis (NASH) represents only a part of a wide spectrum of non-alcoholic fatty liver disease (NAFLD) and its prevalence is only 2-3% in the general population. Diabetes mellitus increases the risk for severe necroinflammation. The diagnosis rests on the hallmark histological features. Liver biopsy is essential for positive diagnosis and prognostication of NASH. The aim of this study was to evaluate the correlation between NASH and risk factor like diabetes, BMI and other risk factors. MATERIALS AND METHODS 36 patients with histologically confirmed NASH with elevated liver aminotransferase and negative markers for other diseases admitted to our institution from Sept-2012 to August-2014, were included in the study, meeting our inclusion & exclusion criteria. Investigations were done & data was collected. Data were pooled & interpreted using standard statistical methods. RESULTS Twenty out of thirty-six patients had diabetes in our study i.e. 55.6% were diabetes. 22 out of 36 patients i.e. 61.1% had BMI >28 kg/m2 . the mean waist circumference in our study was 93.13 Cm. 15 out of 24 female patients i.e. 62.5% females had WC>88 cm and 8 out of 12 male patients i.e. 66.7% males had WC >102 cm., 20 out of 36 patients i.e. 55.6% patients fulfilled at least 3 out of 5 criteria and therefore had insulin resistance syndrome or metabolic syndrome. CONCLUSION Patients with NASH are typically asymptomatic unless cirrhosis develops. 97.22% patients were dyslipidaemics. NASH may be considered an additional features of insulin resistance & metabolic syndrome. Age, gender, waist circumference, BMI, ALT, AST: ALT ratio, serum triglyceride levels, HTN & BAAT score are independent predictors of NASH.
Authors and Affiliations
Uma Shankar Mishra, Jogendra Patra
Keywords
Related Articles
- EP ID EP455670
- DOI 10.18410/jebmh/2018/132
- Views 47
- Downloads 0
A CLINICAL STUDY ON CHARACTERISTICS OF AMBLYOPIA PRESENTING IN A TERTIARY EYE CARE CENTRE
BACKGROUND Amblyopia is characterized by decrease in best corrected visual acuity which can be unilateral or bilateral with no identifiable cause in the eye and visual pathway. Early diagnosis of amblyopia is very essent...
CERVICAL ACID PHOSPHATASE: EVALUATION AS AN ADJUVANT TO PAPANICOLAOU SMEAR SCREENING IN CERVICAL CANCER DETECTION
INTRODUCTION: Carcinoma of cervix accounts for 15% of all cancers diagnosed worldwide and is the second most common cancer in women. In the year 2000 there were over 4,71,000 new cases diagnosed and 2,88,000 deaths from...
SEROPREVALENCE OF HEPATITIS B AND C INFECTION AMONG BLOOD DONORS IN VIJAYPUR DISTRICT KARNATAKA: A COMPARATIVE STUDY
Hepatitis B infection has become one of major health problems worldwide. It causes approximately 1-2 million deaths per year worldwide. India has a population of more than 1.2 billion and comprises of 43 million people p...
A STUDY ON COMPLICATIONS ASSOCIATED WITH MEASLES VACCINATION AMONG CHILDREN OF PATNA, BIHAR
BACKGROUND The aim of the study is to search out the incidence of complications of measles immunisation in malnourished children. MATERIALS AND METHODS Sample selected from OPD Paediatric Department, PMCH, Patna, over a...
ROPIVACAINE VERSUS LIDOCAINE FOR EPISIOTOMY-A RANDOMISED DOUBLE BLIND STUDY
BACKGROUND Episiotomy is a most common surgical procedure for parturients during vaginal delivery. The problem encountered with episiotomy is pain, which is maximum during first 24 hours and may be severe enough to distu...