Successful treatment of chronic disseminated candidiasis in acute myeloid leukemia patient
Journal Title: Ege Tıp Dergisi - Year 2014, Vol 53, Issue 4
Abstract
Chronic disseminated candidiasis (CDC) is a type of systemic disseminated candida infection and affects neutropenic patients. In this case report, a patient with acute myeloid leukemia (AML) who was diagnosed with CDC during remission induction chemotherapy and treated with amphotericin B and fluconazole respectively is reported. After chemotherapy, a fever that was unresponsive to broad spectrum antibiotic treatment occurred in the patient. Liposomal amphotericin B (lip-amp-B) treatment was started. Serum galactomannan (GM) screening and blood cultures were negative. High resolution computed tomography (CT) was normal. Lip-amp-B treatment was stopped after an afebrile, non-neutropenic period was documented. After all treatment was stopped, the patient became febrile again and abdominal pain occurred. The serum alkaline phosphatase (ALP) level was increased. Blood cultures and GM test were negative and an abdominal CT showed multiple nodular lesions in the spleen. CDC was considered. The patient was treated successfully with amphotericin B. This should be kept in mind in cases of CDC in AML patients who were treated with chemotherapy especially if the fever cannot be controlled although broad spectrum antibiotics.
Authors and Affiliations
E K Özturk, N Soyer, S Bayraktaroglu, M Hekimgil, B Arda
Keywords
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- EP ID EP349293
- DOI 10.19161/etd.344093
- Views 108
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