Sumac-Loaded Nano-Phytosome Improves Memory Impairment in the 6-Hydroxydopamine-Lesion Rat Model of Parkinson's Disease
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Introduction: Parkinson’s disease (PD) is the second prevalent neurodegenerative disease generally characterized by the irreversible loss of dopaminergic neurons. Clinically, PD is manifested as motor symptoms and nonmotor symptoms. The nonmotor symptoms of PD include cognitive impairment. Sumac belongs to the genus Rhus, which contains flavonoid compounds. Studies related to this plant have shown that the extracts of Sumac have antioxidant properties. Water-soluble phytoconstituents such as flavonoids in sumac are poorly absorbed, either because of their large size of molecular or due to their insignificant lipid solubility which resulted in poor bioavailability. Nanophytosomes show more bioavailability as compared to conventional herbal extracts and reaching the systemic circulation. The aim of this study was to investigate the effect of sumac and sumac nano-phytosome extracts on cognitive impairment in animal model of Parkinson's disease. Method: The experiments were conducted using Wistar male rats (200–250 g). The rats were divided into the following groups: i) Control ii) positive control iii) 6- OHDA iv) 6-OHDA infused supplemented with 40mg/kg sumac extract (6-OHDA + SE) v) 6-OHDA infused supplemented with 40mg/kg sumac nano phytosome (6-OHDA + SNP). Parkinson's model was made by the unilateral injection of 6-OHDA (10 μg in 2 μl/site) into the right striatum (AP, −0.7; L, −3.0; DV, −5.5). After 24 h of injection of 6-OHDA, the rats in the SE and SNP group were treated with sumac and sumac nano phytosome by gavage (40 mg/kg body weight) for 21 days. Also, Rats in the positive control group received the same dose of Sumac nano phytosome. Rats in the 6-OHDA group and control group were given normal saline. After last gavage, memory impairment in all groups evaluated by the novel object test. Result: The results showed that injection of 6-hydroxydopamine decreases discrimination index (p<0.001) and treatment of nano-phytosomes effectively increases cognitive impairment compared with the 6-OHDA group (p<0.001). Discussion: The present study was aimed to a stable sumac-loaded nano phytosome formulation to improve its antioxidant feature and bioavailability. Furthermore, in this study, the Sumac and sumac nano phytosome probably have been shown to improve cognitive impairment after 21 days in 6- hydroxydopamine-induced Parkinson's model.
Authors and Affiliations
Seyedeh Negar Setareh, Akbar Hajizadeh Moghaddam, Vahid Hasantabar
Keywords
Related Articles
- EP ID EP677953
- DOI 10.29088/GCNR-2020.44
- Views 210
- Downloads 0
Effects of Quercetin Loaded Magnetic Nanoparticles on Electrophysiological and Behavioural Disturbances in the Animal Models of Epilepsy
Epilepsy is one of the most common neurological disorder, characterized by repetitive seizures and various mental health problems. Currently more than 30% of epilepsy cases are resistant to the treatment. It is believed...
The Neuroprotective Effect of Ursolic Acid Associated with Inflammation Factors: IL-10, IL β after the Induction of Severe Traumatic Brain Injury in Rats
Introduction: Ursolic Acid (UA) is a Penta cyclic triterpene compound which Reduces cerebral edema and improves neurological deficits after TBI, leading to increased Nrf2 protein and increased expression of reductase-1...
Nano Phytosome Quercetin Ameliorates Cognitive Impairment Induced by Maternal Isolation in Rat Pups
Introduction: Autism is a kind of neurodevelopmental disorder that the etiology of one is not known, but several genetic and environmental factors increase the risk of spectrum of disorders. Daily maternal isolation dur...
How would Dexmedetomidine have Protective Effects on the Neurological Scores, Brain Edema and Brain-Blood Barrier Post to Serious Traumatic Brain Damage in Male Rats? (The Possible Role of MMP-9)
Introduction: Dexmedetomidine DEX is known as a α2-adrenergic receptor agonist. It is used as a short-acting analgesic drug. In this study, we investigated the effects of neural protection of the DEX after induction of...
Inhibition of Hippocampal Astrocytic Connexin-43 Reduces the Naloxone-Induced Withdrawal Signs in Morphine Dependent Rats
Background and Objective: Drug addiction is an ectopic form of learning, changes synaptic plasticity in various part of brain such as hippocampus. Morphine dependency cause a significant changes in the balance of excita...