Nano Phytosome Quercetin Ameliorates Cognitive Impairment Induced by Maternal Isolation in Rat Pups
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Introduction: Autism is a kind of neurodevelopmental disorder that the etiology of one is not known, but several genetic and environmental factors increase the risk of spectrum of disorders. Daily maternal isolation during the perinatal life enhance the risk of neuropsychiatric disorders and impairment in cognitive behavior. Quercetin is flavonoid that is widely exist plant-derived foods. Although the quercetin plays an important role as antioxidant, its usage the pharmaceutical field is limited because of their concentrations are very low to cross blood-brain. In this study, to solve this problems, nano phytosome of quercetin is used to maximize output in therapy of ADS. Method: Male and female rats were mated with pregnancy determined. Newborn rats categories in several groups. All groups except control group exposure to single separation from their mother for 3 H per day from postnatal days 1-9. After the lactation period, rats except ADS group were treated by Quercetin (10 and 40 mg/kg) and nano phytosome of Quercetin (10and 40 mg/kg) for 21 days. During the 36-40 days after their birth we perform novel object test. Results: We demonstrated that daily maternal isolation in perinatal life lead to autistic-like symptoms. The discrimination index for novel object test in ASD group was meaningfully lower than control group (P<0/001). nano phytosome quercetin (10 mg/kg) and nano phytosome quercetin (40 mg/kg) treatment for 30 days significantly (P<0/05) was significantly increased in compare to autism group. Discussion: In the present study we used to maternal separation to create autism-like model. We reported that the lack of communication of mother with newborn rats during the perinatal life lead to increase the neuropsychiatric disorders such as memory impairment over its lifespan. Here, the rat pups were isolated from their mothers for 3 h per day from postnatal day 1_9. The result of behavioral study illustrated that maternal-separated rat pups showed low discrimination index in their novel object test. However, nano phytosome quercetin (10 and 40 mg/kg) treatment increased the discrimination index and improved memory impairment.
Authors and Affiliations
Ali Eslami, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani Jelodar
Keywords
Related Articles
- EP ID EP677948
- DOI 10.29088/GCNR-2020.39
- Views 175
- Downloads 1
The Relevance between Vitamin D, Folic Acid, and Vitamin B in Multiple Sclerosis
Introduction: Multiple sclerosis (MS) is the most common progressive neurologic disability associated with demyelination in the central nervous system. Factors that cause this disease include low levels of serum vitamin...
The Role of Tamoxifen (A Selective Estrogen Receptor Modulator) on Neurological Score, Blood-Brain Barrier and Brain Edema after Traumatic Brain Injury in Male Rats: The Role of Matrix Metalloproteinase-9
Introduction: Tamoxifen is an oral medication which is used for the treatment of breast cancer, and it acts on an estrogen receptor for agonist or antagonistic activity (effects) due to its effects on the environment. T...
Organization of Feeding-Related Neuronal Ensembles in Invertebrate Model Animals
Today disorders that are associated with feeding behavior is a big issue. To manage them it is necessary to understand at first feeding behavior on different levels including neuronal, endocrine, biochemical, molecular...
Sumac-Loaded Nano-Phytosome Improves Memory Impairment in the 6-Hydroxydopamine-Lesion Rat Model of Parkinson's Disease
Introduction: Parkinson’s disease (PD) is the second prevalent neurodegenerative disease generally characterized by the irreversible loss of dopaminergic neurons. Clinically, PD is manifested as motor symptoms and nonmo...
Decreasing Social Problems in Children with Autism Spectrum Disorder: Effect of Behavioral Intervention on Neural Asymmetry in Frontal Lobe
Background and aims: Autism is a neuro-developmental disorder that impresses on social interaction, communication and stereotyped behavioral patterns. The aims of this study were evaluating the effectiveness of pivotal...