SUMMARIZATION OF FREE RADICALS AND ANTIOXIDANT THERAPY
Journal Title: ASIAN JOURNAL OF NATURAL & APPLIED SCIENCES - Year 2018, Vol 7, Issue 2
Abstract
The aim of the paper is to show that (1) the relation between free radicals and pathology in the human, (2) the roles of endogenous and exogenous antioxidants in antioxidant therapy and (3) the future direction of antioxidant therapy. Lipid peroxidation is a free radical-mediated process. The peroxidation of polyunsaturated fatty acids is implicated in several pathologic conditions including atherosclerosis, myocardial infraction, inflammation, aging, and cancer. There are defence mechanisms presenting in cells and extracellular fluid for controlled over production of free radicals and reactive oxygen species. The important defence mechanisms are enzymatic and non-enzymatic mechanism. When endogenous antioxidative defence machanisms can not work or imbalance, the excess free radicals cause pathophysiological process. Thus, antioxidant therapy is useful for diseases relating to lipid peroxidation. In selection of diseases that we candidate for antioxidant therapy, we should differential between those that have oxidative damage as a primary mechanism at the core of their pathogenesis on the one hand and diseases in which oxidative damage represents a late consequence of primary mechanisms. Cancer and neurodegenerative diseases could probably be included in the list of such diseases.
Authors and Affiliations
Chalerm Saiin, Khesorn Nantachit, Dammrong Santiarwornt
Keywords
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