Survival Outcome and Its Predictors for Treated Patients with Glioblastoma Multiforme-A Single Centre Retrospective Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background: Glioblastoma multiforme is the most aggressive form of primary brain tumour with a median survival 1 year. Aim: To assess the survival outcome and predictive factors for theglioblastoma multiforme patients who were treated with combined modality approach. Methods and materials: We have analyzed retrospectively 30 patients of Glioblastoma multiforme (GBM) diagnosed and treated in our oncology department during the period of March 2014 to March 2017. Inclusion criteria for this study was biopsy proven GBM patients who underwent maximal safe resection and postoperativechemo radiotherapy. Data regarding age, gender, histopathology, extent of surgery, performance status, radiotherapy and chemotherapy details were collected.Kaplan meier analysis was used to find out the median survival of the patients. Both univariate and multivariate analysis were done to assess the predictive factors for survival by using Cox regression model. Results: The median survival time for patients with GBM is 4.1months. Both univariate and multivariate analysis showedperformance status had significant impact over the survival.(p=0.01,0.002 respectively).Patients who had completed full dose of radiotherapy showed a trend towards better survival in multivariate analysis(p=0.09). Conclusion: Despite multimodality aggressive management, survival of patients with newly diagnosed GBM is poor. Predictive factors will help to identify the subgroup of patients with better survival.
Authors and Affiliations
Dr S. Jeeva, Dr. Arun ramanan, Dr. Sowmiya KR
Keywords
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- EP ID EP467732
- DOI 10.9790/0853-1802141317.
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