SUSTAIN OPHTHALMIC DELIVERY OF LEVOFLOXACIN FROM A pH -TRIGGERED IN SITU GELLING SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Most eye diseases are treated with topical application of eye drops. The poor bioavailability and therapeutic response exhibited by these conventional eye drops due to rapid precorneal elimination of the drug may be overcome by the use of in situ gelling systems that are instilled as drops into the eye and undergo a sol-to-gel transition in the cul-de-sac. Hence, the purpose of the present work was to develop Sustain Ophthalmic delivery of Levofloxacin from a pH-triggered in situ gelling system. Polyacrylic acid (Carbopol 934) was used as the gelling agent in combination with hydroxypropyl methylcellulose (Methocel K4M) and HPMC K100LV which acted as a viscosity enhancing agent. Compatibility studies of the drug excipients were carried out using FTIR. The prepared formulations were characterized for clarity, pH, drug content, Gelling capacity, Rheological studies, in vitro drug release study, sterility study and stability study.
Authors and Affiliations
Rajesh Asija , Nikunj Patel , Smit Shah , Sangeeta Asija , Ashok Barupal
Keywords
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