SYNTHESIS AND ANTHELMINTIC ACTIVITY OF 3-(2-HYDRAZINO BENZOTHIAZOLES)-SUBSTITUTED INDOLE-2-ONE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Benzothiazoles and Isatins have emerged as structurally novel anthelmintics. Therefore various 3-(2-hydrazino benzothiazoles)-substituted Indole-2-one, were synthesized by condensation of various 2-hydrazino benzothiazole, 2-hydrazino 1,4-thaizine and 2-acid hydrazide benzothiazoles with different substituted Indole -2,3-diones (Isatins). The structures of the synthesized compounds (A1-6)(B1-6)(C1-6) were characterized by FTIR, 1HNMR and elemental analysis. All the synthesized compounds were screened for anthelmintic activity by using Indian adult earthwarms (pheretima postuma). The compounds A4-5, B4, C4 have showed good paralytic time, compared to standard albendazole drug.
Authors and Affiliations
Suresh CH , Venkateshwara Rao, Jayaveera KN , Subudhi S. K.
Keywords
Related Articles
- EP ID EP114045
- DOI -
- Views 104
- Downloads 0
EVALUATION OF ANDROGRAPHIS PANICULATA (BURMF) WALL EX NEES, LEAF EXTRACTS AND ANDROGRAPHOLIDE ON GASTROINTESTINAL PATHOGENS
Andrographis paniculata (BurmF) Wall Ex Nees called as Kalmegh or "King of Bitters is used in southeast Asia for treating several ailments. The aim of this study was to determine the antibacterial activity of Andrographi...
AN IMPROVED RP-HPLC METHOD FOR THE QUANTITATIVE DETERMINATION AND VALIDATION OF LEVETIRACETAM IN BULK AND PHARMACEUTICAL FORMULATION
The present study depicts the development of a validated RP-HPLC method for the determination of the Levetiracetam in pharmaceutical tablet dosage form. RP-HPLC method was developed by utilizing Welchrom C18 Column (250...
ASSESSMENT OF MERCURY RELEASE FROM DENTAL AMALGAM: AN IN VITRO STUDY
Exposure to mercury from dental amalgam restoration, with possible negative health effects, has generally been considered to occur via either erosion or evaporation directly from the surface of fillings, followed by inge...
GC/MS DETERMINATION OF BIOACTIVE COMPONENTS OF PLEUROTUS OSTREATUS
In this study, the bioactive components of Pleurotus ostreatus have been evaluated using GC/MS. The chemical compositions of the hydroalcholic extract of Pleurotus ostreatus were investigated using Perkin-Elmer Chromatog...
ANALGESIC ACTIVITY OF PET ETHER, AQUEOUS, AND HYDRO-ETHANOLIC LEAF EXTRACTS OF ASPILIA AFRICANA (PERS) C.D. ADAMS (ASTERACEAE) IN RODENTS
Traditionally, Aspilia africana is used in the management of pain in Ghana and most parts of West Africa. This study therefore investigated the analgesic effect of the petroleum ether, aqueous, and hydro-ethanolic leaf e...